UNLABELLED: The purpose of this study was to clarify the changes in hippocampal perfusion in mild-to-moderate Alzheimer's disease using PET and (15)O-labeled water. METHODS: Sixteen patients with probable mild-to-moderate Alzheimer's disease (age: 68.1+/-11.3 yr; MMSE: 21.1+/-4.5) and 10 normal volunteers (age: 65.1+/-8.2 yr) were studied. Regional cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using (15)O-labeled water autoradiographic method, C(15)O-gas inhalation technique and PET. RESULTS: Although the mean CBF in the parietotemporal region was significantly lower in the patient group than in the control group, the mean CBF in the hippocampus did not show significant reduction between the two groups, both in absolute and relative values. There was no significant regional CBV difference between the two groups. Parietotemporal perfusion correlated well with cognitive scores, both in absolute and relative values, in Alzheimer's disease, but hippocampal perfusion did not correlate well. CONCLUSION: Hippocampal perfusion was preserved in mild-to-moderate Alzheimer's disease.
UNLABELLED: The purpose of this study was to clarify the changes in hippocampal perfusion in mild-to-moderate Alzheimer's disease using PET and (15)O-labeled water. METHODS: Sixteen patients with probable mild-to-moderate Alzheimer's disease (age: 68.1+/-11.3 yr; MMSE: 21.1+/-4.5) and 10 normal volunteers (age: 65.1+/-8.2 yr) were studied. Regional cerebral blood flow (CBF) and cerebral blood volume (CBV) were measured using (15)O-labeled water autoradiographic method, C(15)O-gas inhalation technique and PET. RESULTS: Although the mean CBF in the parietotemporal region was significantly lower in the patient group than in the control group, the mean CBF in the hippocampus did not show significant reduction between the two groups, both in absolute and relative values. There was no significant regional CBV difference between the two groups. Parietotemporal perfusion correlated well with cognitive scores, both in absolute and relative values, in Alzheimer's disease, but hippocampal perfusion did not correlate well. CONCLUSION: Hippocampal perfusion was preserved in mild-to-moderate Alzheimer's disease.
Authors: Christian Habeck; Norman L Foster; Robert Perneczky; Alexander Kurz; Panagiotis Alexopoulos; Robert A Koeppe; Alexander Drzezga; Yaakov Stern Journal: Neuroimage Date: 2008-02-14 Impact factor: 6.556
Authors: Koon-Pong Wong; Mirwais Wardak; Weber Shao; Magnus Dahlbom; Vladimir Kepe; Jie Liu; Nagichettiar Satyamurthy; Gary W Small; Jorge R Barrio; Sung-Cheng Huang Journal: Eur J Nucl Med Mol Imaging Date: 2009-10-31 Impact factor: 9.236
Authors: Anna Zimny; Joanna Bladowska; Małgorzata Neska; Kamila Petryszyn; Maciej Guziński; Paweł Szewczyk; Jerzy Leszek; Marek Sąsiadek Journal: Med Sci Monit Date: 2013-02-04
Authors: Juergen Dukart; Robert Perneczky; Stefan Förster; Henryk Barthel; Janine Diehl-Schmid; Bogdan Draganski; Hellmuth Obrig; Emiliano Santarnecchi; Alexander Drzezga; Andreas Fellgiebel; Richard Frackowiak; Alexander Kurz; Karsten Müller; Osama Sabri; Matthias L Schroeter; Igor Yakushev Journal: PLoS One Date: 2013-02-25 Impact factor: 3.240