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Literature DB >> 9473734

Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.

L Sun¹, A M Hui, Y Kanai, M Sakamoto, S Hirohashi.

Abstract

The present study was designed to determine whether changes in DNA methyltransferase (DNA MTase) expression are involved in hepatocarcinogenesis. We examined DNA MTase expression in normal liver tissue (with no remarkable histological findings), liver tissue showing chronic hepatitis or cirrhosis, which are generally thought to be precancerous conditions, and hepatocellular carcinomas (HCCs) using the reverse-transcriptase polymerase chain reaction assay. DNA MTase mRNA levels were significantly higher in liver tissue showing chronic hepatitis and cirrhosis (DNA MTase mRNA/beta-actin mRNA ratio = 0.30 +/- 0.22, n = 24, P < 0.01) than in normal liver tissue either from patients with liver metastatic lesions of colonic cancer (0.14 +/- 0.05, n = 6) or from patients with HCCs (0.16 +/- 0.07, n = 3). DNA MTase mRNA levels were even higher in HCC tissue (0.34 +/- 0.18, n = 29). These results suggest that increased DNA MTase expression may be an early event during hepatocarcinogenesis. DNA MTase is a potential target for HCC preventive therapy.

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Year: 1997 PMID： 9473734 PMCID： PMC5921336 DOI： 10.1111/j.1349-7006.1997.tb00345.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

hepatocellnlar carcinoma meth‐yltransferase reverse‐transcriptase polymerase chain reaction

33 in total

Review 1. DNA methylation errors and cancer.

Authors: P A Jones
Journal: Cancer Res Date: 1996-06-01 Impact factor: 12.701

10. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.

Authors: Yoshimasa Saito; Yae Kanai; Michiie Sakamoto; Hidetsugu Saito; Hiromasa Ishii; Setsuo Hirohashi
Journal: Proc Natl Acad Sci U S A Date: 2002-07-10 Impact factor: 11.205

Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.

Review 1. DNA methylation errors and cancer.

2. Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.

3. Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors.

4. Inactivation of p16INK4 in hepatocellular carcinoma.

5. Increased cytosine DNA-methyltransferase activity during colon cancer progression.

6. Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.

7. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.

8. Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis.

9. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.

10. Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis.

1. Effect of 5-Aza-2'-deoxycytidine on the P16 tumor suppressor gene in hepatocellular carcinoma cell line HepG2.

Review 2. Does oxidative stress participate in the development of hepatocellular carcinoma?

3. DNA methyltransferase expression in odontogenic cysts and tumours.

4. Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells.

Review 5. Clinical implications of DNA methylation in hepatocellular carcinoma.

6. Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.

Review 7. 5-hydroxymethylcytosine: a new insight into epigenetics in cancer.

Review 8. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.

9. Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.

10. Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.