Literature DB >> 9473209

Structure and function of heparin-binding EGF-like growth factor (HB-EGF).

K M Davis-Fleischer1, G E Besner.   

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated signaling, and role in several important biological systems.

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Year:  1998        PMID： 9473209     DOI： 10.2741/a241

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  21 in total

1.  Receptor-based antidote for diphtheria.

Authors:  Jeong-Heon Cha; Joanna S Brooke; Mee Young Chang; Leon Eidels
Journal:  Infect Immun       Date:  2002-05       Impact factor: 3.441

2.  Heparin-binding EGF-like growth factor protects pericytes from injury.

Authors:  Xiaoyi Yu; Andrei Radulescu; Chun-Liang Chen; Iyore O James; Gail E Besner
Journal:  J Surg Res       Date:  2010-09-17       Impact factor: 2.192

Review 3.  Can we protect the gut in critical illness? The role of growth factors and other novel approaches.

Authors:  Jessica A Dominguez; Craig M Coopersmith
Journal:  Crit Care Clin       Date:  2010-07       Impact factor: 3.598

4.  Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.

Authors:  S l Fu; I Bottoli; M Goller; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

5.  Epithelial separation theory for post-tonsillectomy secondary hemorrhage: evidence in a mouse model and potential heparin-binding epidermal growth factor-like growth factor therapy.

Authors:  Daniel M Beswick; Chloe Santa Maria; Noel F Ayoub; Robson Capasso; Peter Luke Santa Maria
Journal:  Eur Arch Otorhinolaryngol       Date:  2017-11-29       Impact factor: 2.503

6.  HB-EGF protects the lungs after intestinal ischemia/reperfusion injury.

Authors:  Iyore A O James; Chun-Liang Chen; Guangcun Huang; Hong-Yi Zhang; Markus Velten; Gail E Besner
Journal:  J Surg Res       Date:  2010-04-24       Impact factor: 2.192

Review 7.  The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis.

Authors:  Kathryn J Rowland; Pamela M Choi; Brad W Warner
Journal:  Semin Pediatr Surg       Date:  2013-05       Impact factor: 2.754

8.  High expression of heparanase is significantly associated with dedifferentiation and lymph node metastasis in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA and via HIF1a to HB-EGF and bFGF.

Authors:  Andreas-Claudius Hoffmann; Ryutaro Mori; Daniel Vallbohmer; Jan Brabender; Uta Drebber; Stephan E Baldus; Ellen Klein; Mizutomo Azuma; Ralf Metzger; Christina Hoffmann; Arnulf H Hoelscher; Kathleen D Danenberg; Klaus L Prenzel; Peter V Danenberg
Journal:  J Gastrointest Surg       Date:  2008-08-13       Impact factor: 3.452

9.  Heparin-binding epidermal growth factor-like growth factor attenuates acute lung injury and multiorgan dysfunction after scald burn.

Authors:  Jeffrey Lutmer; Daniel Watkins; Chun-Liang Chen; Markus Velten; Gail Besner
Journal:  J Surg Res       Date:  2013-06-12       Impact factor: 2.192

10.  Heparin-binding epidermal growth factor-like growth factor: hypoxia-inducible expression in vitro and stimulation of neurogenesis in vitro and in vivo.

Authors:  Kunlin Jin; Xiao Ou Mao; Yunjuan Sun; Lin Xie; Lan Jin; Eiichiro Nishi; Michael Klagsbrun; David A Greenberg
Journal:  J Neurosci       Date:  2002-07-01       Impact factor: 6.167
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