Literature DB >> 947147

Screening large numbers of compounds in a model based on mortality of Trypanosoma rhodesiense infected mice.

L Rane, D S Rane, K E Kinnamon.   

Abstract

A test system has been developed to evaluate the trypanosomicidal activity of large numbers of candidate drugs. Based on mortality of mice with blood induced Trypanosoma rhodesiense infections, it serves as a primary screen or as a secondary and confirmatory test for active compounds. Over 5,500 selected compounds have been tested; more than 6% were active.

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Year:  1976        PMID： 947147     DOI： 10.4269/ajtmh.1976.25.395

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  7 in total

1.  Trypanosoma rhodesiense infection in congenitally athymic (nude) mice.

Authors:  G H Campbell; K M Esser; S M Phillips
Journal:  Infect Immun       Date:  1978-06       Impact factor: 3.441

2.  Adoptive transfer of variant-specific resistance to Trypanosoma rhodesiense with B lymphocytes and serum.

Authors:  G H Campbell; S M Phillips
Journal:  Infect Immun       Date:  1976-11       Impact factor: 3.441

3.  Activity of 2-acetylpyridine thiosemicarbazones against Trypanosoma rhodesiense in vitro.

Authors:  R A Casero; D L Klayman; G E Childs; J P Scovill; R E Desjardins
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

4.  Antibody-dependent cytotoxicity against Trypanosoma rhodesiense mediated through an alternative complement pathway.

Authors:  B Flemmings; C Diggs
Journal:  Infect Immun       Date:  1978-03       Impact factor: 3.441

Review 5.  Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

Authors:  M P Barrett; D W Boykin; R Brun; R R Tidwell
Journal:  Br J Pharmacol       Date:  2007-07-09       Impact factor: 8.739

6.  Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.

Authors:  Gabriele Pohlig; Sonja C Bernhard; Johannes Blum; Christian Burri; Alain Mpanya; Jean-Pierre Fina Lubaki; Alfred Mpoo Mpoto; Blaise Fungula Munungu; Patrick Mangoni N'tombe; Gratias Kambau Manesa Deo; Pierre Nsele Mutantu; Florent Mbo Kuikumbi; Alain Fukinsia Mintwo; Augustin Kayeye Munungi; Amadeu Dala; Stephen Macharia; Constantin Miaka Mia Bilenge; Victor Kande Betu Ku Mesu; Jose Ramon Franco; Ndinga Dieyi Dituvanga; Richard R Tidwell; Carol A Olson
Journal:  PLoS Negl Trop Dis       Date:  2016-02-16

Review 7.  Targeting Channels and Transporters in Protozoan Parasite Infections.

Authors:  Anna Meier; Holger Erler; Eric Beitz
Journal:  Front Chem       Date:  2018-03-27       Impact factor: 5.221
  7 in total

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