Amphibians provide new insights into taste-bud development.

Until recently, the predominant model of taste-bud development was one of neural induction: ingrowing sensory fibers were thought to induce taste-bud differentiation late in embryonic development. Recent experimental studies, however, show that the development of taste buds is independent of their innervation. In amphibian embryos, the ability to generate taste buds is an intrinsic feature of the oropharyngeal epithelium long before the region becomes innervated. These studies indicate that patterning of the oropharyngeal epithelium occurs during gastrulation, and suggest that taste buds or their progenitors play the dominant role in the development of their own innervation.