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Literature DB >> 946404

The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents.

Abstract

Among 15 chelating agents tested, sodium-2,3-dimercaptopropane 1 sulfonate (DMPS), 2,3-dimercaptopropanol (BAL), sodium-mercaptoethyliminodiacetate (MEIDA), and D-penicillamine (PA) exerted an influence on the excretion of Hg and its distribution in the organs. The excretion pattern however, is different for these compounds, and, from the practical point of view, a favourable effect is exhibited only by DMPS which enhances the urinary excretion rate and lowers the Hg-concentration in all organs.

Entities: Chemical Species

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Year: 1976 PMID： 946404 DOI： 10.1007/bf00333982

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

25 in total

1. Treatment of chronic mercurialism with N-acetyl-penicillamine.

Authors: L D PAGNOTTO; H G BRUGSCH; H B ELKINS
Journal: Am Ind Hyg Assoc J Date: 1960-10

2. [THE EFFECT OF CHELATING AGENTS ON THE BEHAVIOR OF MERCURY IN THE BODY].

Authors: V NIGROVIC
Journal: Arzneimittelforschung Date: 1963-09

Review 3. Distribution, tissue binding and toxicity of mercurials.

Authors: J T MacGregor; T W Clarkson
Journal: Adv Exp Med Biol Date: 1974 Impact factor: 2.622

4. [On the influence of chelating agents on the excretion and the behavior of mercury in acute mercury poisoning].

Authors: V Eybl; J Sýkora; F Mertl
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1965-11-04

5. Enterohepatic circulation of 64Cu, 52Mn and 203Hg in rats.

Authors: M Cikrt
Journal: Arch Toxikol Date: 1973-08-30

6. [Pharmacokinetic studies on 14 C-labelled penicillamine].

Authors: F Planas-Bohne
Journal: Arzneimittelforschung Date: 1972-09

7. The effects of penicillamine on the body burdens of several heavy metals.

Authors: A J Silva; D G Fleshman; B Shore
Journal: Health Phys Date: 1973-05 Impact factor: 1.316

8. Combined effect of sodium maleate and some thiol compounds on mercury excretion and redistribution in rats.

Authors: L Magos; T Stoytchev
Journal: Br J Pharmacol Date: 1969-01 Impact factor: 8.739

9. Studies on the metabolism of methyl mercury and dimethyl mercury in mice.

Authors: K Ostlund
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1969

10. The toxicities of compounds related to 2,3-dimercaptopropanol (BAL) with a note on their relative therapeutic efficiency.

Authors: O G FITZHUGH; G WOODARD
Journal: J Pharmacol Exp Ther Date: 1946-08 Impact factor: 4.030

8 in total

8. Case report: severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration.

Authors: Paul I Dargan; Lucy J Giles; Craig I Wallace; Ivan M House; Alison H Thomson; Richard J Beale; Alison L Jones
Journal: Crit Care Date: 2003-02-17 Impact factor: 9.097

8 in total

The excretion and distribution of inorganic mercury in the rat as influenced by several chelating agents.

1. Treatment of chronic mercurialism with N-acetyl-penicillamine.

2. [THE EFFECT OF CHELATING AGENTS ON THE BEHAVIOR OF MERCURY IN THE BODY].

Review 3. Distribution, tissue binding and toxicity of mercurials.

4. [On the influence of chelating agents on the excretion and the behavior of mercury in acute mercury poisoning].

5. Enterohepatic circulation of 64Cu, 52Mn and 203Hg in rats.

6. [Pharmacokinetic studies on 14 C-labelled penicillamine].

7. The effects of penicillamine on the body burdens of several heavy metals.

8. Combined effect of sodium maleate and some thiol compounds on mercury excretion and redistribution in rats.

9. Studies on the metabolism of methyl mercury and dimethyl mercury in mice.

10. The toxicities of compounds related to 2,3-dimercaptopropanol (BAL) with a note on their relative therapeutic efficiency.

1. Distribution and excretion of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate in the rat.

Review 2. 2,3-Dimercapto-1-propanesulphonate in heavy metal poisoning.

3. Effect of oral therapy with monoisoamyl meso-2,3-dimercaptosuccinate on 203Hg retention in rats.

4. [Suicide by intravenous injection of sublimate solution].

5. Chelation of lead with DMPS and BAL in rats injected with lead.

6. The effect of mercuric chloride on the excretion of two urinary enzymes in the rat.

7. Mobilized mercury in subjects with varying exposure to elemental mercury vapour.

8. Case report: severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration.