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Literature DB >> 9463376

Synapsin I is structurally similar to ATP-utilizing enzymes.

L Esser¹, C R Wang, M Hosaka, C S Smagula, T C Südhof, J Deisenhofer.

Abstract

Synapsins are abundant synaptic vesicle proteins with an essential regulatory function in the nerve terminal. We determined the crystal structure of a fragment (synC) consisting of residues 110-420 of bovine synapsin I; synC coincides with the large middle domain (C-domain), the most conserved domain of synapsins. SynC molecules are folded into compact domains and form closely associated dimers. SynC monomers are strikingly similar in structure to a family of ATP-utilizing enzymes, which includes glutathione synthetase and D-alanine:D-alanine ligase. SynC binds ATP in a Ca2+-dependent manner. The crystal structure of synC in complex with ATPgammaS and Ca2+ explains the preference of synC for Ca2+ over Mg2+. Our results suggest that synapsins may also be ATP-utilizing enzymes.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9463376 PMCID： PMC1170447 DOI： 10.1093/emboj/17.4.977

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

33 in total

1. Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins.

Authors: K Matsuda; K Mizuguchi; T Nishioka; H Kato; N Go; J Oda
Journal: Protein Eng Date: 1996-12

Review 2. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.

Authors: T C Südhof; A J Czernik; H T Kao; K Takei; P A Johnston; A Horiuchi; S D Kanazir; M A Wagner; M S Perin; P De Camilli
Journal: Science Date: 1989-09-29 Impact factor: 47.728

Review 3. Molecular tuning of ion binding to calcium signaling proteins.

Authors: J J Falke; S K Drake; A L Hazard; O B Peersen
Journal: Q Rev Biophys Date: 1994-08 Impact factor: 5.318

4. Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.

Authors: G L Waldrop; I Rayment; H M Holden
Journal: Biochemistry Date: 1994-08-30 Impact factor: 3.162

5. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain.

Authors: M Sriram; J Osipiuk; B Freeman; R Morimoto; A Joachimiak
Journal: Structure Date: 1997-03-15 Impact factor: 5.006

6. Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit.

Authors: J P Steiner; E Ling; V Bennett
Journal: J Biol Chem Date: 1987-01-15 Impact factor: 5.157

7. Annexin VI binds to a synaptic vesicle protein, synapsin I.

Authors: M Inui; T Watanabe; K Sobue
Journal: J Neurochem Date: 1994-11 Impact factor: 5.372

8. Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1.

Authors: A J Baines; V Bennett
Journal: Nature Date: 1985 May 30-Jun 5 Impact factor: 49.962

9. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.

Authors: W T Wolodko; M E Fraser; M N James; W A Bridger
Journal: J Biol Chem Date: 1994-04-08 Impact factor: 5.157

10. Short-term synaptic plasticity is altered in mice lacking synapsin I.

Authors: T W Rosahl; M Geppert; D Spillane; J Herz; R E Hammer; R C Malenka; T C Südhof
Journal: Cell Date: 1993-11-19 Impact factor: 41.582

39 in total

Review 1. Synapsins as regulators of neurotransmitter release.

Authors: S Hilfiker; V A Pieribone; A J Czernik; H T Kao; G J Augustine; P Greengard
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1999-02-28 Impact factor: 6.237

2. The biosynthesis of UDP-d-FucNAc-4N-(2)-oxoglutarate (UDP-Yelosamine) in Bacillus cereus ATCC 14579: Pat and Pyl, an aminotransferase and an ATP-dependent Grasp protein that ligates 2-oxoglutarate to UDP-4-amino-sugars.

Authors: Soyoun Hwang; Zi Li; Yael Bar-Peled; Avi Aronov; Jaime Ericson; Maor Bar-Peled
Journal: J Biol Chem Date: 2014-11-03 Impact factor: 5.157

Synapsin I is structurally similar to ATP-utilizing enzymes.

1. Crystal structure of glutathione synthetase at optimal pH: domain architecture and structural similarity with other proteins.

Review 2. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.

Review 3. Molecular tuning of ion binding to calcium signaling proteins.

4. Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.

5. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain.

6. Nearest neighbor analysis for brain synapsin I. Evidence from in vitro reassociation assays for association with membrane protein(s) and the Mr = 68,000 neurofilament subunit.

7. Annexin VI binds to a synaptic vesicle protein, synapsin I.

8. Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1.

9. The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5-A resolution.

10. Short-term synaptic plasticity is altered in mice lacking synapsin I.

Review 1. Synapsins as regulators of neurotransmitter release.

2. The biosynthesis of UDP-d-FucNAc-4N-(2)-oxoglutarate (UDP-Yelosamine) in Bacillus cereus ATCC 14579: Pat and Pyl, an aminotransferase and an ATP-dependent Grasp protein that ligates 2-oxoglutarate to UDP-4-amino-sugars.

3. Structural domains involved in the regulation of transmitter release by synapsins.

Review 4. The role of synapsins in neuronal development.

Review 5. Synapsin III: role in neuronal plasticity and disease.

6. Rapid model building of beta-sheets in electron-density maps.

Review 7. Synaptic Vesicle Clusters at Synapses: A Distinct Liquid Phase?

8. Rapid model building of alpha-helices in electron-density maps.

9. The synapsin gene family in basal chordates: evolutionary perspectives in metazoans.

10. Rapid chain tracing of polypeptide backbones in electron-density maps.