Literature DB >> 9461663

Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine.

Y Maruyama1, H Kuribara, M Morita, M Yuzurihara, S T Weintraub.   

Abstract

The principal active anxiolytic components in Saiboku-to, an Oriental herbal medicine, have been isolated and identified as magnolol (5,5'-di-2-propenyl-1,1'-biphenyl-2,2'-diol) and honokiol (3',5-di-2-propenyl-1,1'-biphenyl-2,4'-diol). Evaluation by means of an elevated plus-maze test showed that honokiol was at least 5000 times more potent than Saiboku-to when mice were treated orally for 7 days.

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Year:  1998        PMID： 9461663     DOI： 10.1021/np9702446

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  28 in total

1.  Honokiol and magnolol increase the number of [3H] muscimol binding sites three-fold in rat forebrain membranes in vitro using a filtration assay, by allosterically increasing the affinities of low-affinity sites.

Authors:  R F Squires; J Ai; M R Witt; P Kahnberg; E Saederup; O Sterner; M Nielsen
Journal:  Neurochem Res       Date:  1999-12       Impact factor: 3.996

2.  In vitro growth inhibition of human cancer cells by novel honokiol analogs.

Authors:  Jyh Ming Lin; A S Prakasha Gowda; Arun K Sharma; Shantu Amin
Journal:  Bioorg Med Chem       Date:  2012-04-03       Impact factor: 3.641

3.  Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.

Authors:  Franck Amblard; Baskaran Govindarajan; Benjamin Lefkove; Kimberly L Rapp; Mervi Detorio; Jack L Arbiser; Raymond F Schinazi
Journal:  Bioorg Med Chem Lett       Date:  2007-06-10       Impact factor: 2.823

4.  The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

Authors:  Mikhail Alexeev; Denise K Grosenbaugh; David D Mott; Janet L Fisher
Journal:  Neuropharmacology       Date:  2012-03-12       Impact factor: 5.250

Review 5.  Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.

Authors:  Mélanie Poivre; Pierre Duez
Journal:  J Zhejiang Univ Sci B       Date:  2017 Mar.       Impact factor: 3.066

6.  Systemic application of honokiol prevents cisplatin ototoxicity without compromising its antitumor effect.

Authors:  Xiaodong Tan; Yingjie Zhou; Aditi Agarwal; Michelle Lim; Yingyue Xu; Yueming Zhu; Joseph O'Brien; Elizabeth Tran; Jing Zheng; David Gius; Claus-Peter Richter
Journal:  Am J Cancer Res       Date:  2020-12-01       Impact factor: 6.166

Review 7.  Plant-derived anticancer agents: a promising treatment for bone metastasis.

Authors:  Patricia Juárez
Journal:  Bonekey Rep       Date:  2014-12-10

Review 8.  Honokiol, a multifunctional antiangiogenic and antitumor agent.

Authors:  Levi E Fried; Jack L Arbiser
Journal:  Antioxid Redox Signal       Date:  2009-05       Impact factor: 8.401

9.  Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2.

Authors:  Dennis Y Chuang; Agnes Simonyi; Jiankun Cui; Dennis B Lubahn; Zezong Gu; Grace Y Sun
Journal:  Neuromolecular Med       Date:  2016-06-23       Impact factor: 3.843

10.  Honokiol inhibits tumor necrosis factor-α-stimulated rat aortic smooth muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.

Authors:  Shuli Fan; Xu Li; Jie Lin; Sijiao Chen; Jinhua Shan; Guoxian Qi
Journal:  Inflammation       Date:  2014-02       Impact factor: 4.092
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