Literature DB >> 17587572

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.

Franck Amblard1, Baskaran Govindarajan, Benjamin Lefkove, Kimberly L Rapp, Mervi Detorio, Jack L Arbiser, Raymond F Schinazi.   

Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.

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Year:  2007        PMID： 17587572      PMCID： PMC2001289          DOI： 10.1016/j.bmcl.2007.06.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

Review 1.  Claisen rearrangement over the past nine decades.

Authors:  Ana M Martín Castro
Journal:  Chem Rev       Date:  2004-06       Impact factor: 60.622

2.  Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells.

Authors:  K R LaMontagne; M A Moses; D Wiederschain; S Mahajan; J Holden; H Ghazizadeh; D A Frank; J L Arbiser
Journal:  Am J Pathol       Date:  2000-12       Impact factor: 4.307

3.  Activities of 3'-azido-3'-deoxythymidine nucleotide dimers in primary lymphocytes infected with human immunodeficiency virus type 1.

Authors:  R F Schinazi; J P Sommadossi; V Saalmann; D L Cannon; M Y Xie; G C Hart; G A Smith; E F Hahn
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

4.  Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.

Authors:  Lieven J Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung K Chu; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

5.  EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta.

Authors:  C M Teng; S M Yu; C C Chen; Y L Huang; T F Huang
Journal:  Life Sci       Date:  1990       Impact factor: 5.037

6.  Ras inactivation of the retinoblastoma pathway by distinct mechanisms in NIH 3T3 fibroblast and RIE-1 epithelial cells.

Authors:  K Pruitt; R G Pestell; C J Der
Journal:  J Biol Chem       Date:  2000-12-29       Impact factor: 5.157

7.  Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan.

Authors:  Tomoyuki Esumi; Gouki Makado; Haifeng Zhai; Yasuhiro Shimizu; Yasuhide Mitsumoto; Yoshiyasu Fukuyama
Journal:  Bioorg Med Chem Lett       Date:  2004-05-17       Impact factor: 2.823

8.  Two antiplatelet agents from Magnolia officinalis.

Authors:  C M Teng; C C Chen; F N Ko; L G Lee; T F Huang; Y P Chen; H Y Hsu
Journal:  Thromb Res       Date:  1988-06-15       Impact factor: 3.944

9.  Metabolites of orally administered Magnolia officinalis extract in rats and man and its antidepressant-like effects in mice.

Authors:  Takahiro Nakazawa; Takaaki Yasuda; Keisuke Ohsawa
Journal:  J Pharm Pharmacol       Date:  2003-11       Impact factor: 3.765

10.  Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.

Authors:  Xianhe Bai; Francesca Cerimele; Masuko Ushio-Fukai; Muhammad Waqas; Paul M Campbell; Baskaran Govindarajan; Channing J Der; Traci Battle; David A Frank; Keqiang Ye; Emma Murad; Wolfgang Dubiel; Gerald Soff; Jack L Arbiser
Journal:  J Biol Chem       Date:  2003-06-19       Impact factor: 5.157
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  19 in total

1.  In vitro growth inhibition of human cancer cells by novel honokiol analogs.

Authors:  Jyh Ming Lin; A S Prakasha Gowda; Arun K Sharma; Shantu Amin
Journal:  Bioorg Med Chem       Date:  2012-04-03       Impact factor: 3.641

Review 2.  Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.

Authors:  Mélanie Poivre; Pierre Duez
Journal:  J Zhejiang Univ Sci B       Date:  2017 Mar.       Impact factor: 3.066

Review 3.  Use of Polyphenolic Compounds in Dermatologic Oncology.

Authors:  Adilson Costa; Michael Yi Bonner; Jack L Arbiser
Journal:  Am J Clin Dermatol       Date:  2016-08       Impact factor: 7.403

4.  Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage.

Authors:  Adilson Costa; Gustavo Facchini; Ana Lúcia T A Pinheiro; Michelle S da Silva; Michael Y Bonner; Jack Arbiser; Samara Eberlin
Journal:  Int J Dermatol       Date:  2017-02-22       Impact factor: 2.736

Review 5.  Preferential killing of cancer cells with mitochondrial dysfunction by natural compounds.

Authors:  Gang Chen; Feng Wang; Dunyaporn Trachootham; Peng Huang
Journal:  Mitochondrion       Date:  2010-08-14       Impact factor: 4.160

6.  Honokiol and Magnolol Inhibit CXCL10 and CXCL11 Production in IL-27-Stimulated Human Oral Epithelial Cells.

Authors:  Yoshitaka Hosokawa; Ikuko Hosokawa; Kazumi Ozaki; Takashi Matsuo
Journal:  Inflammation       Date:  2018-12       Impact factor: 4.092

Review 7.  Honokiol, a multifunctional antiangiogenic and antitumor agent.

Authors:  Levi E Fried; Jack L Arbiser
Journal:  Antioxid Redox Signal       Date:  2009-05       Impact factor: 8.401

8.  In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).

Authors:  Guo-Ying Zuo; Xin-Juan Zhang; Jun Han; Yu-Qing Li; Gen-Chun Wang
Journal:  BMC Complement Altern Med       Date:  2015-12-01       Impact factor: 3.659

9.  Akt Kinase Intervenes in Flavivirus Replication by Interacting with Viral Protein NS5.

Authors:  Laura Albentosa-González; Nereida Jimenez de Oya; Armando Arias; Pilar Clemente-Casares; Miguel Ángel Martin-Acebes; Juan Carlos Saiz; Rosario Sabariegos; Antonio Mas
Journal:  Viruses       Date:  2021-05-12       Impact factor: 5.048

10.  Cardiovascular protection of magnolol: cell-type specificity and dose-related effects.

Authors:  Jennifer Hui-Chun Ho; Chuang-Ye Hong
Journal:  J Biomed Sci       Date:  2012-07-31       Impact factor: 8.410
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