| Literature DB >> 9459511 |
H Izaabel1, H J Garchon, S Caillat-Zucman, G Beaurain, O Akhayat, J F Bach, A Sanchez-Mazas.
Abstract
HLA DRB1, DQA1 and DQB1 polymorphisms were analyzed by PCR-SSO typing in a sample of the Moroccan population from Souss. Uneven allelic frequency distributions are observed at each locus, with particularly high frequencies for DRB1*0701, DRB1*0301, DQA1*0501, DQA1*0201, and DQB1*0201. Only three haplotypes (DRB1*0701-DQA1*0201-DQB1*0201, DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*11-DQA1*0501-DQB1*0301) account for nearly 50% of the total gene frequencies. A genetic distance analysis reveals that the Moroccan population is close to the Spanish and the Algerians, who live in geographically neighboring areas. However, the Souss population is also characterized by a lower level of genetic diversity compared to other African and European populations from the Mediterranean area. This may be the result of a rapid genetic drift due to their likely geographical and/or cultural isolation.Entities:
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Year: 1998 PMID： 9459511 DOI： 10.1111/j.1399-0039.1998.tb02954.x
Source DB: PubMed Journal: Tissue Antigens ISSN： 0001-2815