Literature DB >> 9459208

Migration and gap junctional intercellular communication determine the metastatic phenotype of human tumor cell lines.

A Navolotski1, A Rumjnzev, H Lü, D Proft, P Bartholmes, K S Zänker.   

Abstract

Gap junctional intercellular communication (GJIC) as well as cell migration play an essential role in the metastatic cascade of human tumors. We show a dependence of metastatogenic phenotypes of human tumor cells (cell lines T 24, SCC-25, MDA-MB-361 and SK-BR-3) from the GJIC and the migration activity. The GJIC was studied by microinjection of the fluorescent dye Lucifer Yellow (LY) and cell migration was studied by investigating the locomotion of the tumor cells in 3-dimensional collagen matrices. Diminished GJIC seems to be more influential for the metastatic phenotype than modulation of the locomotory behavior of the tumor cells.

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Year:  1997        PMID： 9459208     DOI： 10.1016/s0304-3835(97)00329-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  5 in total

1.  Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer.

Authors:  L Kanczuga-Koda; S Sulkowski; A Lenczewski; M Koda; A Wincewicz; M Baltaziak; M Sulkowska
Journal:  J Clin Pathol       Date:  2006-04       Impact factor: 3.411

Review 2.  The role of connexin-mediated cell-cell communication in breast cancer metastasis.

Authors:  G D Carystinos; A Bier; G Batist
Journal:  J Mammary Gland Biol Neoplasia       Date:  2001-10       Impact factor: 2.673

3.  Connexin membrane materials as potent inhibitors of breast cancer cell migration.

Authors:  Silvia Ferrati; Avinash K Gadok; Ashlee D Brunaugh; Chi Zhao; Lara A Heersema; Hugh D C Smyth; Jeanne C Stachowiak
Journal:  J R Soc Interface       Date:  2017-08       Impact factor: 4.118

4.  Computational identification of surrogate genes for prostate cancer phases using machine learning and molecular network analysis.

Authors:  Rudong Li; Xiao Dong; Chengcheng Ma; Lei Liu
Journal:  Theor Biol Med Model       Date:  2014-08-23       Impact factor: 2.432

5.  Differential expression of the RANKL/RANK/OPG system is associated with bone metastasis in human non-small cell lung cancer.

Authors:  Xianbo Peng; Wei Guo; Tingting Ren; Zhiyuan Lou; Xinchang Lu; Shuai Zhang; Qunshan Lu; Yifeng Sun
Journal:  PLoS One       Date:  2013-03-13       Impact factor: 3.240
  5 in total

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