Literature DB >> 9458077

Atypical adenomatous hyperplasia of the prostate: a premalignant lesion?

L Cheng1, A Shan, J C Cheville, J Qian, D G Bostwick.   

Abstract

To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31-35, 8p12-21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.

Entities:  

Mesh：

Year:  1998        PMID： 9458077

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  12 in total

1.  Genetic analysis of prostatic atypical adenomatous hyperplasia (adenosis).

Authors:  J A Doll; X Zhu; J Furman; Z Kaleem; C Torres; P A Humphrey; H Donis-Keller
Journal:  Am J Pathol       Date:  1999-09       Impact factor: 4.307

Review 2.  [Non-neoplastic alterations of the prostate. Why should pathologists know them?].

Authors:  A Erbersdobler
Journal:  Pathologe       Date:  2013-09       Impact factor: 1.011

3.  Laser capture microdissection in the genomic and proteomic era: targeting the genetic basis of cancer.

Authors:  Barbara Domazet; Gregory T Maclennan; Antonio Lopez-Beltran; Rodolfo Montironi; Liang Cheng
Journal:  Int J Clin Exp Pathol       Date:  2008-03-15

4.  Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma.

Authors:  Liang Cheng; Timothy D Jones; Ryan P McCarthy; John N Eble; Mingsheng Wang; Gregory T MacLennan; Antonio Lopez-Beltran; Ximing J Yang; Michael O Koch; Shaobo Zhang; Chong-Xian Pan; Lee Ann Baldridge
Journal:  Am J Pathol       Date:  2005-05       Impact factor: 4.307

5.  Histopathological Analysis of False-positive Lesions in mpMRI/TRUS Fusion Prostate Biopsy.

Authors:  Ryoken Yamanaka; Yohei Sekino; Takashi Babasaki; Kohei Kobatake; Hiroyuki Kitano; Kenichiro Ikeda; Keisuke Goto; Tetsutaro Hayashi; Jun Teishima; Yukio Takeshima; Yukiko Honda; Kazuo Awai; Nobuyuki Hinata
Journal:  In Vivo       Date:  2022 Jan-Feb       Impact factor: 2.155

Review 6.  Precursor lesions to prostatic adenocarcinoma.

Authors:  Jonathan I Epstein
Journal:  Virchows Arch       Date:  2008-12-02       Impact factor: 4.064

7.  Identical allelic losses in mature teratoma and other histologic components of malignant mixed germ cell tumors of the testis.

Authors:  Kevin M Kernek; Thomas M Ulbright; Shaobo Zhang; Steven D Billings; Oscar W Cummings; John D Henley; Helen Michael; Matteo Brunelli; Guido Martignoni; Richard S Foster; John N Eble; Liang Cheng
Journal:  Am J Pathol       Date:  2003-12       Impact factor: 4.307

8.  Molecular genetic evidence for different clonal origins of epithelial and stromal components of phyllodes tumor of the prostate.

Authors:  Ryan P McCarthy; Shaobo Zhang; David G Bostwick; Junqi Qian; John N Eble; Mingsheng Wang; Haiqun Lin; Liang Cheng
Journal:  Am J Pathol       Date:  2004-10       Impact factor: 4.307

9.  High-grade prostatic intraepithelial neoplasia of the prostate: the precursor lesion of prostate cancer.

Authors:  Debra L Zynger; Ximing Yang
Journal:  Int J Clin Exp Pathol       Date:  2008-12-22

10.  Immunohistochemical expression of prostate tumour overexpressed 1 (PTOV1) in atypical adenomatous hyperplasia (AAH) of the prostate: additional evidence linking (AAH) to adenocarcinoma.

Authors:  Roberta Mazzucchelli; Marina Scarpelli; Francesca Barbisan; Alfredo Santinelli; Antonio Lopez-Beltran; Liang Cheng; Rodolfo Montironi
Journal:  Cell Oncol (Dordr)       Date:  2012-11-07       Impact factor: 6.730
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