Literature DB >> 945167

Behavioural effects of a new non-phenylethylamine anorexigenic agent: mazindol.

F Zambotti, M O Carruba, F Barzaghi, L Vicentini, A Groppetti, P Mantegazza.   

Abstract

Mazindol, a new anorexigenic agent which possesses a different chemical structure from phenylethylamine derivatives such as amphetamine, causes anorexia along with increases in locomotor activity and body temperature. Mazindol also induces stereotyped behaviour and, if injected into rats with unilateral nigro-striatal lesions, causes turning towards the lesioned side. Mazindol-induced anorexia is antagonized by pretreatment with alpha-methyl-p-tyrosine or pimozide. Pimozide pretreatment prevents the rotation induced by Mazindol in rats with unilateral nigro-striatal lesions. The involvement of dopamine in the mechanism whereby Mazindol elicits anorexia and turning behaviour is discussed.

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Year:  1976        PMID： 945167     DOI： 10.1016/0014-2999(76)90094-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Mazindol and amphetamine as inhibitors of the uptake and releasers of 3H-dopamine by rat striatal synaptosomes.

Authors:  M O Carruba; G B Picotti; F Zambotti; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-05       Impact factor: 3.000

2.  The anorectic action of mazindol.

Authors:  K F Sweeney
Journal:  Ir J Med Sci       Date:  1978-08       Impact factor: 1.568

3.  Food-intake and locomotor activity: effects of mazindol and spiperone [proceedings].

Authors:  S J Cooper; K F Sweeney
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

4.  Mazindol anorexia is mediated by activation of dopaminergic mechanisms.

Authors:  Z L Kruk; M R Zarrindast
Journal:  Br J Pharmacol       Date:  1976-11       Impact factor: 8.739

5.  Effect of mazindol on brain dopamine turnover in spiperone-treated rats.

Authors:  R W Fuller; H D Snoddy
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

6.  Fluoxetine at anorectic doses does not have properties of a dopamine uptake inhibitor.

Authors:  R W Fuller; S K Hemrick-Luecke; H D Snoddy
Journal:  J Neural Transm Gen Sect       Date:  1994

7.  Effects of mazindol, fenfluramine and chlorimipramine on the 5-hydroxytryptamine uptake and storage mechanisms in rat brain: similarities and differences.

Authors:  M O Carruba; G B Picotti; F Zambotti; P Mantegazza
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-11       Impact factor: 3.000

8.  Repeated administration of mazindol reduces spontaneous pain-related behaviors without modifying bone density and microarchitecture in a mouse model of complete Freund's adjuvant-induced knee arthritis.

Authors:  L E Robledo-González; A Martínez-Martínez; V M Vargas-Muñoz; R I Acosta-González; R Plancarte-Sánchez; M Anaya-Reyes; C Fernández Del Valle-Laisequilla; J G Reyes-García; J M Jiménez-Andrade
Journal:  J Pain Res       Date:  2017-07-27       Impact factor: 3.133

9.  A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening.

Authors:  Yasuhito Shimada; Minoru Hirano; Yuhei Nishimura; Toshio Tanaka
Journal:  PLoS One       Date:  2012-12-26       Impact factor: 3.240
  9 in total

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