Literature DB >> 438800

Effect of mazindol on brain dopamine turnover in spiperone-treated rats.

R W Fuller, H D Snoddy.   

Abstract

Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1--10 mg/kg dose range of mazindol and was maximum within 1 hour after maxzindol injection into rats pretreated 1 hour previously with spiperone. In spiperone-pretreated rats, mazindol accelerated the disappearance of dopamine after the inhibition of dopamine synthesis by alpha-methyltyrosine. Mazindol apparently resembles amfonelic acid, methylphenidate, and cocaine in facilitating the impulse-mediated release of dopamine.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 438800     DOI： 10.1007/bf01252698

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  16 in total

1.  Actions of amfonelic acid and other non-amphetamine stimulants on the dopamine neuron.

Authors:  P A Shore
Journal:  J Pharm Pharmacol       Date:  1976-11       Impact factor: 3.765

2.  A SENSITIVE METHOD FOR SPECTROPHOTOFLUOROMETRIC ASSAY OF CATECHOLAMINES.

Authors:  C C CHANG
Journal:  Int J Neuropharmacol       Date:  1964-12

3.  On the effect of anorectic drugs on striatum homovanillic acid in rats.

Authors:  A Jori; E Dolfini
Journal:  Pharmacol Res Commun       Date:  1974-04

4.  On the mode of action of central stimulatory agents.

Authors:  S B Ross
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1977-10

5.  Procedure for the simultaneous determination of dopamine, 3-methoxy-4-hydroxyphenylacetic acid, and 3,4-dihydroxyphenylacetic acid in brain.

Authors:  P F Spano; N H Neff
Journal:  Anal Biochem       Date:  1971-07       Impact factor: 3.365

6.  Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.

Authors:  M O Carruba; A Groppetti; P Mantegazza; L Vicentini; F Zambotti
Journal:  Br J Pharmacol       Date:  1976-04       Impact factor: 8.739

7.  Pharmacological analysis of a new anorexic substance: 5-hydroxy-5(4'-chlorophenyl)-2, 3-dihydro-5H-imidazo-(2, 1-a) isoindole (Mazindol).

Authors:  J H Gogerty; C Penberthy; L C Iorio; J H Trapold
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-04

8.  Effect of lergotrile on 3,4-dihydroxyphenylacetic acid (DOPAC) concentration and dopamine turnover in rat brain.

Authors:  R W Fuller; K W Perry
Journal:  J Neural Transm       Date:  1978       Impact factor: 3.575

9.  Methylphenidate-like effects of the new antidepressant drug nomifensine (HOE 984).

Authors:  C Braestrup; J Scheel-Krüger
Journal:  Eur J Pharmacol       Date:  1976-08       Impact factor: 4.432

10.  Mazindol anorexia is mediated by activation of dopaminergic mechanisms.

Authors:  Z L Kruk; M R Zarrindast
Journal:  Br J Pharmacol       Date:  1976-11       Impact factor: 8.739
View more
  2 in total

1.  The effects of GBR 12909, a dopamine re-uptake inhibitor, on monoaminergic neurotransmission in rat striatum, limbic forebrain, cortical hemispheres and substantia nigra.

Authors:  H Nissbrandt; G Engberg; E Pileblad
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1991-07       Impact factor: 3.000

2.  Fluoxetine at anorectic doses does not have properties of a dopamine uptake inhibitor.

Authors:  R W Fuller; S K Hemrick-Luecke; H D Snoddy
Journal:  J Neural Transm Gen Sect       Date:  1994
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.