| Literature DB >> 9450748 |
A Glinka1, W Wu, H Delius, A P Monaghan, C Blumenstock, C Niehrs.
Abstract
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.Entities:
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Year: 1998 PMID： 9450748 DOI： 10.1038/34848
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962