Literature DB >> 9448585

Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis.

E Larsson1, A Müssener, D Heinegård, L Klareskog, T Saxne.   

Abstract

The aim of this study was to investigate whether serum levels of cartilage and bone macromolecules can be used to monitor tissue destruction in experimental arthritis in rats. Serum levels of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP) were measured by novel immunoassays in the chronic and destructive arthritis induced in DA rats after immunization with autologous rat native collagen type II in Freund's incomplete adjuvant. Increased serum levels of COMP and BSP were seen on day 21 after immunization, and even higher levels were observed on day 28 at termination of the experiment, paralleling increases in the clinical joint score and histopathological signs of cartilage and bone erosions. Serum analyses of these markers may be a useful non-invasive way of monitoring tissue involvement in experimental arthritis and possibly the effects of therapeutic interventions aimed at retarding tissue destruction.

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Year:  1997        PMID： 9448585     DOI： 10.1093/rheumatology/36.12.1258

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN： 0263-7103


  7 in total

Review 1.  [Rheumatology update. Current knowledge of etiology, pathophysiology, diagnosis, and therapy of selected arthritic disorders. Part I: pathogenesis and differential diagnosis].

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Journal:  Med Klin (Munich)       Date:  1999-09-15

2.  Release of cartilage and bone macromolecules into synovial fluid: differences between psoriatic arthritis and rheumatoid arthritis.

Authors:  B Mânsson; A Gülfe; P Geborek; D Heinegård; T Saxne
Journal:  Ann Rheum Dis       Date:  2001-01       Impact factor: 19.103

3.  Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study.

Authors:  T Conrozier; T Saxne; C S Fan; P Mathieu; A M Tron; D Heinegård; E Vignon
Journal:  Ann Rheum Dis       Date:  1998-09       Impact factor: 19.103

4.  Quantitative dynamic models of arthritis progression in the rat.

Authors:  Justin C Earp; Debra C Dubois; Richard R Almon; William J Jusko
Journal:  Pharm Res       Date:  2008-08-30       Impact factor: 4.200

5.  Intra-articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect.

Authors:  B Murat Cınar; Gurkan Ozkoc; Filiz Bolat; Oguz Karaeminogullari; Nurzen Sezgin; Reha N Tandogan
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-03-25       Impact factor: 4.342

6.  Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis.

Authors:  L A Joosten; E Lubberts; M M Helsen; T Saxne; C J Coenen-de Roo ; D Heinegård; W B van den Berg
Journal:  Arthritis Res       Date:  1999-10-26

7.  Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model.

Authors:  Andreas Baranowski; Ludwig Schlemmer; Katharina Förster; Ekaterina Slotina; Tim Mickan; Sebastian Truffel; Anja Klein; Stefan G Mattyasovszky; Alexander Hofmann; Ulrike Ritz; Pol M Rommens
Journal:  Drug Des Devel Ther       Date:  2019-07-30       Impact factor: 4.162
  7 in total

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