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Literature DB >> 9448276

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

Abstract

Targeted disruption of the mouse TOP3alpha gene encoding DNA topoisomerase IIIalpha was carried out to study the physiological functions of the mammalian type IA DNA topoisomerase. Whereas heterozygous top3alpha+/- mutant mice were found to resemble phenotypically their TOP3alpha+/+ litermates, no viable top3alpha-/- homozygotes were found among over 100 progeny of top3alpha+/- intercrosses. Examination of embryos dissected from decidual swellings and in vitro culturing of blastocysts from top3alpha+/- intercrosses showed that implantation of top3alpha-/- embryos and the induction of decidualization could occur, but viability of these embryos was severely compromised at an early stage of development. The requirement of mouse DNA topoisomerase IIIalpha during early embryogenesis is discussed in terms of its plausible role in chromosome replication and its interaction with the RecQ/SGS1 family of DNA helicases, whose members include the Bloom's syndrome and the Werner's syndrome gene products.

Entities: Disease Gene Species

Mesh：

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Year: 1998 PMID： 9448276 PMCID： PMC18654 DOI： 10.1073/pnas.95.3.1010

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

1. Cloning and sequencing of Escherichia coli mutR shows its identity to topB, encoding topoisomerase III.

Authors: M A Schofield; R Agbunag; M L Michaels; J H Miller
Journal: J Bacteriol Date: 1992-08 Impact factor: 3.490

2. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

Authors: K Tanabe; Y Ikegami; R Ishida; T Andoh
Journal: Cancer Res Date: 1991-09-15 Impact factor: 12.701

3. Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I.

Authors: M Drolet; P Phoenix; R Menzel; E Massé; L F Liu; R J Crouch
Journal: Proc Natl Acad Sci U S A Date: 1995-04-11 Impact factor: 11.205

4. The Bloom's syndrome gene product is homologous to RecQ helicases.

Authors: N A Ellis; J Groden; T Z Ye; J Straughen; D J Lennon; S Ciocci; M Proytcheva; J German
Journal: Cell Date: 1995-11-17 Impact factor: 41.582

5. Hypernegative supercoiling of the DNA template during transcription elongation in vitro.

Authors: M Drolet; X Bi; L F Liu
Journal: J Biol Chem Date: 1994-01-21 Impact factor: 5.157

6. Regulation of Escherichia coli topA gene transcription: involvement of a sigmaS-dependent promoter.

Authors: H Qi; R Menzel; Y C Tse-Dinh
Journal: J Mol Biol Date: 1997-04-04 Impact factor: 5.469

7. Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.

Authors: E Fritz; S H Elsea; P I Patel; M S Meyn
Journal: Proc Natl Acad Sci U S A Date: 1997-04-29 Impact factor: 11.205

8. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

Authors: S Gangloff; J P McDonald; C Bendixen; L Arthur; R Rothstein
Journal: Mol Cell Biol Date: 1994-12 Impact factor: 4.272

9. Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase.

Authors: R A Kim; J C Wang
Journal: J Biol Chem Date: 1992-08-25 Impact factor: 5.157

10. A single ataxia telangiectasia gene with a product similar to PI-3 kinase.

Authors: K Savitsky; A Bar-Shira; S Gilad; G Rotman; Y Ziv; L Vanagaite; D A Tagle; S Smith; T Uziel; S Sfez; M Ashkenazi; I Pecker; M Frydman; R Harnik; S R Patanjali; A Simmons; G A Clines; A Sartiel; R A Gatti; L Chessa; O Sanal; M F Lavin; N G Jaspers; A M Taylor; C F Arlett; T Miki; S M Weissman; M Lovett; F S Collins; Y Shiloh
Journal: Science Date: 1995-06-23 Impact factor: 47.728

68 in total

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis.

1. Cloning and sequencing of Escherichia coli mutR shows its identity to topB, encoding topoisomerase III.

2. Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

3. Overexpression of RNase H partially complements the growth defect of an Escherichia coli delta topA mutant: R-loop formation is a major problem in the absence of DNA topoisomerase I.

4. The Bloom's syndrome gene product is homologous to RecQ helicases.

5. Hypernegative supercoiling of the DNA template during transcription elongation in vitro.

6. Regulation of Escherichia coli topA gene transcription: involvement of a sigmaS-dependent promoter.

7. Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.

8. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

9. Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase.

10. A single ataxia telangiectasia gene with a product similar to PI-3 kinase.

1. Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIbeta.

2. The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.

3. The mechanism of type IA topoisomerases.

Review 4. RecQ helicases; at the crossroad of genome replication, repair, and recombination.

5. Top3 processes recombination intermediates and modulates checkpoint activity after DNA damage.

6. Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

7. DNA Topology and Topoisomerases: Teaching a "Knotty" Subject.

8. Characterization of two isoforms of a human DnaJ homologue, HSJ2.

9. Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.

Review 10. Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.