G von Minckwitz1, S D Costa. 1. Klinik für Gynäkologie und Geburtshilfe, Johann Wolfgang Goethe-Universität Frankfurt. minckwitz@em.uni-frankfurt.de
Abstract
CLINICAL RESULTS: Docetaxel is a taxan which has proven high efficacy in the treatment of breast cancer. The results are consistent throughout all phases of clinical evaluation. High response rates have been observed especially for women after failure of anthracyclins or with liver metastases. Response rates are superior to doxorubicin, while the extent of the side effects is comparable. CONCLUSION: Due to the different toxicity profile a combination of docetaxel and anthracyclins is feasible and has already been demonstrated in early clinical trials. The role of the combinatory treatments in first line or adjuvant setting is currently under investigation.
CLINICAL RESULTS:Docetaxel is a taxan which has proven high efficacy in the treatment of breast cancer. The results are consistent throughout all phases of clinical evaluation. High response rates have been observed especially for women after failure of anthracyclins or with liver metastases. Response rates are superior to doxorubicin, while the extent of the side effects is comparable. CONCLUSION: Due to the different toxicity profile a combination of docetaxel and anthracyclins is feasible and has already been demonstrated in early clinical trials. The role of the combinatory treatments in first line or adjuvant setting is currently under investigation.
Authors: J B Vermorken; W W ten Bokkel Huinink; I A Mandjes; T J Postma; M T Huizing; J J Heimans; J H Beijnen; F Bierhorst; B Winograd; H M Pinedo Journal: Semin Oncol Date: 1995-08 Impact factor: 4.929
Authors: S Jones; E Winer; C Vogel; L Laufman; L Hutchins; M O'Rourke; B Lembersky; D Budman; J Bigley; J Hohneker Journal: J Clin Oncol Date: 1995-10 Impact factor: 44.544
Authors: L Gianni; E Munzone; G Capri; F Fulfaro; E Tarenzi; F Villani; C Spreafico; A Laffranchi; A Caraceni; C Martini Journal: J Clin Oncol Date: 1995-11 Impact factor: 44.544
Authors: A D Seidman; A Tiersten; C Hudis; M Gollub; S Barrett; T J Yao; J Lepore; T Gilewski; V Currie; J Crown Journal: J Clin Oncol Date: 1995-10 Impact factor: 44.544
Authors: Xinrong Guo; Sibylle Loibl; Michael Untch; Volker Möbus; Kathrin Schwedler; Peter A Fasching; Jana Barinoff; Frank Holms; Christoph Thomssen; Dirk M Zahm; Rolf Kreienberg; Maik Hauschild; Holger Eidtmann; Sascha Tauchert; Keyur Mehta; Gunter von Minckwitz Journal: Breast Care (Basel) Date: 2011-08-19 Impact factor: 2.860