Literature DB >> 9445080

Implication of a central cysteine residue and the HHCC domain of Moloney murine leukemia virus integrase protein in functional multimerization.

G A Donzella1, O Leon, M J Roth.   

Abstract

Moloney murine leukemia virus (M-MuLV) IN-IN protein interactions important for catalysis of strand transfer and unimolecular and bimolecular disintegration reactions were investigated by using a panel of chemically modified M-MuLV IN proteins. Functional complementation of an HHCC-deleted protein (Ndelta105) by an independent HHCC domain (Cdelta232) was severely compromised by NEM modification of either subunit. Productive Ndelta105 IN-DNA interactions with a disintegration substrate lacking a long terminal repeat 5'-single-stranded tail also required complementation by a functional HHCC domain. Virus encoding the C209A M-MuLV IN mutation exhibited delayed virion production and replication kinetics.

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Year:  1998        PMID： 9445080      PMCID： PMC124658     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  50 in total

Review 1.  HIV DNA integration: observations and interferences.

Authors:  J Kulkosky; A M Skalka
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1990

2.  Functional domains of Moloney murine leukemia virus integrase defined by mutation and complementation analysis.

Authors:  C B Jonsson; G A Donzella; E Gaucan; C M Smith; M J Roth
Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

3.  Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence.

Authors:  M J Roth; P L Schwartzberg; S P Goff
Journal:  Cell       Date:  1989-07-14       Impact factor: 41.582

4.  Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.

Authors:  P O Brown; B Bowerman; H E Varmus; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

5.  Correct integration of retroviral DNA in vitro.

Authors:  P O Brown; B Bowerman; H E Varmus; J M Bishop
Journal:  Cell       Date:  1987-05-08       Impact factor: 41.582

6.  Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors:  B Hirt
Journal:  J Mol Biol       Date:  1967-06-14       Impact factor: 5.469

7.  Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.

Authors:  S Goff; P Traktman; D Baltimore
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

8.  The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro.

Authors:  R Craigie; T Fujiwara; F Bushman
Journal:  Cell       Date:  1990-08-24       Impact factor: 41.582

9.  The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration.

Authors:  M Katzman; R A Katz; A M Skalka; J Leis
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

10.  Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site.

Authors:  J Colicelli; S P Goff
Journal:  Cell       Date:  1985-09       Impact factor: 41.582
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  6 in total

1.  Functional interactions of the HHCC domain of moloney murine leukemia virus integrase revealed by nonoverlapping complementation and zinc-dependent dimerization.

Authors:  F Yang; O Leon; N J Greenfield; M J Roth
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

2.  Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase.

Authors:  F Yang; M J Roth
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

3.  Blue native PAGE and biomolecular complementation reveal a tetrameric or higher-order oligomer organization of the physiological measles virus attachment protein H.

Authors:  Melinda A Brindley; Richard K Plemper
Journal:  J Virol       Date:  2010-09-22       Impact factor: 5.103

4.  Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis.

Authors:  F M van den Ent; A Vos; R H Plasterk
Journal:  J Virol       Date:  1999-04       Impact factor: 5.103

5.  Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions.

Authors:  Rodrigo A Villanueva; Colleen B Jonsson; Jennifer Jones; Millie M Georgiadis; Monica J Roth
Journal:  Virology       Date:  2003-11-10       Impact factor: 3.616

6.  Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solution.

Authors:  Daniel R Henriquez; Caifeng Zhao; Haiyan Zheng; José J Arbildua; Mónica L Acevedo; Monica J Roth; Oscar Leon
Journal:  BMC Struct Biol       Date:  2013-07-11
  6 in total

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