Literature DB >> 2166782

HIV DNA integration: observations and interferences.

J Kulkosky1, A M Skalka.   

Abstract

DNA integration appears to be an obligatory step for the efficient replication of retroviruses. Studies of the integration reaction for the avian and murine C-type retroviruses have defined the importance of: i) LTR terminal sequences, which are joined to host DNA, and ii) the activity of the retroviral integration protein (IN). The specific requirements for the integration of HIV DNA have not yet been defined. In this review, we survey studies pertinent to this reaction for HIV and extrapolate a mechanism for HIV DNA integration based upon knowledge of the integrative recombination reaction of the C-type retroviruses.

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Year:  1990        PMID： 2166782

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr (1988)        ISSN： 0894-9255


  19 in total

1.  Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases.

Authors:  J Kulkosky; K S Jones; R A Katz; J P Mack; A M Skalka
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

2.  HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts.

Authors:  I Raineri; H P Senn
Journal:  Nucleic Acids Res       Date:  1992-12-11       Impact factor: 16.971

3.  Rapid solution assays for retroviral integration reactions and their use in kinetic analyses of wild-type and mutant Rous sarcoma virus integrases.

Authors:  B Müller; K S Jones; G W Merkel; A M Skalka
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

4.  Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain.

Authors:  T Masuda; V Planelles; P Krogstad; I S Chen
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

5.  Coordinated disintegration reactions mediated by Moloney murine leukemia virus integrase.

Authors:  G A Donzella; C B Jonsson; M J Roth
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

6.  Suppression of HIV-1 Infectivity by Human Glioma Cells.

Authors:  Sheikh Ariful Hoque; Atsushi Tanaka; Salequl Islam; Gias Uddin Ahsan; Atsushi Jinno-Oue; Hiroo Hoshino
Journal:  AIDS Res Hum Retroviruses       Date:  2016-01-07       Impact factor: 2.205

7.  Influence of substrate structure on disintegration activity of Moloney murine leukemia virus integrase.

Authors:  G A Donzella; C B Jonsson; M J Roth
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

8.  Human immunodeficiency virus type 1 DNA synthesis, integration, and efficient viral replication in growth-arrested T cells.

Authors:  G Li; M Simm; M J Potash; D J Volsky
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

9.  Role of the His-Cys finger of Moloney murine leukemia virus integrase protein in integration and disintegration.

Authors:  C B Jonsson; M J Roth
Journal:  J Virol       Date:  1993-09       Impact factor: 5.103

10.  Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.

Authors:  A Mazumder; M Gupta; Y Pommier
Journal:  Nucleic Acids Res       Date:  1994-10-25       Impact factor: 16.971
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