Literature DB >> 9445073

Visna virus dUTPase is dispensable for neuropathogenicity.

G Pétursson1, P Turelli, S Matthíasdóttir, G Georgsson, O S Andrésson, S Torsteinsdóttir, R Vigne, V Andrésdóttir, E Gunnarsson, G Agnarsdóttir, G Quérat.   

Abstract

The major part of the dUTPase-encoding region of the visna virus genome was deleted. Intracerebral injection of the mutant virus resulted in a somewhat reduced viral load compared to that resulting from injection of the wild type, especially in the lungs, but the neuropathogenic effects were comparable. The dUTPase gene is dispensable for induction of lesions in the brain.

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Year:  1998        PMID： 9445073      PMCID： PMC124651     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Pathogenesis of visna. I. Sequential virologic, serologic, and pathologic studies.

Authors:  G Pétursson; N Nathanson; G Georgsson; H Panitch; P A Pálsson
Journal:  Lab Invest       Date:  1976-10       Impact factor: 5.662

2.  Development and regional distribution of deoxyuridine 5'-triphosphatase in rabbit brain.

Authors:  R Spector; B Boose
Journal:  J Neurochem       Date:  1983-10       Impact factor: 5.372

3.  Enhanced activity of deoxyuridine 5'-triphosphatase in regenerating rat liver.

Authors:  S Hokari; Y Sakagishi; K Tsukada
Journal:  Biochem Biophys Res Commun       Date:  1982-09-16       Impact factor: 3.575

4.  Induction of uracil-DNA glycosylase and dUTP nucleotidohydrolase activity in herpes simplex virus-infected human cells.

Authors:  S J Caradonna; Y C Cheng
Journal:  J Biol Chem       Date:  1981-10-10       Impact factor: 5.157

5.  Human deoxyuridine triphosphate nucleotidohydrolase. Purification and characterization of the deoxyuridine triphosphate nucleotidohydrolase from acute lymphocytic leukemia.

Authors:  M V Williams; Y Cheng
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

6.  Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme.

Authors:  M V Williams; D S Parris
Journal:  Virology       Date:  1987-02       Impact factor: 3.616

7.  Expression of viral antigens in the central nervous system of visna-infected sheep: an immunohistochemical study on experimental visna induced by virus strains of increased neurovirulence.

Authors:  G Georgsson; D J Houwers; P A Pálsson; G Pétursson
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

8.  Cell cycle- and differentiation stage-dependent variation of dUTPase activity in higher plant cells.

Authors:  E G Pardo; C Gutiérrez
Journal:  Exp Cell Res       Date:  1990-01       Impact factor: 3.905

9.  Deoxyuridine triphosphate nucleotidohydrolase activity and its correlation with multiplication of erythroid cells in rat spleen.

Authors:  S Hokari; M Hasegawa; Y Sakagishi; G Kikuchi
Journal:  Biochem Int       Date:  1987-05

10.  The occurrence and consequences of deoxyuridine in DNA.

Authors:  R G Richards; L C Sowers; J Laszlo; W D Sedwick
Journal:  Adv Enzyme Regul       Date:  1984
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  8 in total

1.  Evolution and horizontal transfer of dUTPase-encoding genes in viruses and their hosts.

Authors:  A M Baldo; M A McClure
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

Review 2.  Human immunodeficiency virus and AIDS: insights from animal lentiviruses.

Authors:  R J Miller; J S Cairns; S Bridges; N Sarver
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4.  Propagating and detecting an infectious molecular clone of maedi-visna virus that expresses green fluorescent protein.

Authors:  Stefán R Jónsson; Valgerdur Andrésdóttir
Journal:  J Vis Exp       Date:  2011-10-09       Impact factor: 1.355

5.  Genome analysis of small-ruminant lentivirus genotype E: a caprine lentivirus with natural deletions of the dUTPase subunit, vpr-like accessory gene, and 70-base-pair repeat of the U3 region.

Authors:  Ramsés Reina; Elena Grego; Luigi Bertolotti; Daniele De Meneghi; Sergio Rosati
Journal:  J Virol       Date:  2008-11-05       Impact factor: 5.103

6.  The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein.

Authors:  Nickolay Voronin; Eytan Herzig; Amnon Hizi
Journal:  Retrovirology       Date:  2014-08-12       Impact factor: 4.602

Review 7.  dUTPase: the frequently overlooked enzyme encoded by many retroviruses.

Authors:  Amnon Hizi; Eytan Herzig
Journal:  Retrovirology       Date:  2015-08-12       Impact factor: 4.602

Review 8.  Gene Therapy Applications of Non-Human Lentiviral Vectors.

Authors:  Altar M Munis
Journal:  Viruses       Date:  2020-09-29       Impact factor: 5.048
  8 in total

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