Literature DB >> 6137516

Development and regional distribution of deoxyuridine 5'-triphosphatase in rabbit brain.

R Spector, B Boose.   

Abstract

The development and regional distribution of deoxyuridine 5'-triphosphatase (dUTPase) in rabbit brain was studied. After partial purification of the dUTPase activity, newborn brain and liver activities fell from Vmax values of 1.0 and 6.9 nmol/mg protein/min, respectively, to adult levels of 0.1 (brain) and less than 0.01 (liver). The dUTPase activity was evenly distributed throughout the entire adult rabbit brain, and there was no difference in the Km of dUTPase in newborn and adult brain (0.1 microM). The low level of dUTPase in adult brain and the lack of activity in adult liver were not due to inhibitors or phenylmethylsulfonyl fluoride-sensitive proteases. dUTPase in brain, as in other tissues, probably inhibits the misincorporation of uracil into DNA.

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Year:  1983        PMID： 6137516     DOI： 10.1111/j.1471-4159.1983.tb09073.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  10 in total

1.  Metabolism of deoxypyrimidines and deoxypyrimidine antiviral analogs in isolated brain mitochondria.

Authors:  Kathleen A McCann; David W Williams; Edward E McKee
Journal:  J Neurochem       Date:  2012-05-21       Impact factor: 5.372

2.  Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant.

Authors:  D S Threadgill; W K Steagall; M T Flaherty; F J Fuller; S T Perry; K E Rushlow; S F Le Grice; S L Payne
Journal:  J Virol       Date:  1993-05       Impact factor: 5.103

3.  dUTPase-minus caprine arthritis-encephalitis virus is attenuated for pathogenesis and accumulates G-to-A substitutions.

Authors:  P Turelli; F Guiguen; J F Mornex; R Vigne; G Quérat
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

4.  The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 In vivo mutation rate.

Authors:  L M Mansky; S Preveral; L Selig; R Benarous; S Benichou
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

5.  Visna virus dUTPase is dispensable for neuropathogenicity.

Authors:  G Pétursson; P Turelli; S Matthíasdóttir; G Georgsson; O S Andrésson; S Torsteinsdóttir; R Vigne; V Andrésdóttir; E Gunnarsson; G Agnarsdóttir; G Quérat
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

6.  Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.

Authors:  R B Pyles; R L Thompson
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

7.  Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity.

Authors:  D L Lichtenstein; K E Rushlow; R F Cook; M L Raabe; C J Swardson; G J Kociba; C J Issel; R C Montelaro
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

8.  Identification and characterization of pseudorabies virus dUTPase.

Authors:  A Jöns; T C Mettenleiter
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

9.  Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses.

Authors:  P Turelli; G Pétursson; F Guiguen; J F Mornex; R Vigne; G Quérat
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

Review 10.  The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain.

Authors:  Reynold Spector; Conrad E Johanson
Journal:  Mol Brain       Date:  2014-01-10       Impact factor: 4.041
  10 in total

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