Literature DB >> 9441758

Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.

P Liston1, C Lefebvre, W G Fong, J Y Xuan, R G Korneluk.   

Abstract

Genomic and cDNA clones encoding mouse inhibitor of apoptosis protein 1 and 2 (Miap1 and Miap2) were isolated and characterized. The genes encoding the 602-amino-acid MIAP1 protein and the 612-amino-acid MIAP2 protein are contained within a 57-kb locus in a tandem head-to-tail arrangement. The Miap1 gene consists of nine exons spanning 24 kb, and the Miap2 gene consists of seven exons spanning 21 kb. Fluorescence in situ hybridization analysis mapped the locus to chromosome 9A2, which is syntenic with portions of the human 11q22-q23 region containing the human homologues HIAP1 and HIAP2. Sequencing of the complete Miap1 and Miap2 cDNAs revealed an unusually long 5' untranslated region in the Miap2 transcript, which may indicate nonscanning ribosomal initiation of translation.

Entities:  

Mesh：

Substances：

Year:  1997        PMID： 9441758     DOI： 10.1006/geno.1997.5059

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  7 in total

1.  Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system.

Authors:  Martin Holcik; Tyson Graber; Stephen M Lewis; Charles A Lefebvre; Eric Lacasse; Stephen Baird
Journal:  RNA       Date:  2005-09-21       Impact factor: 4.942

2.  Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.

Authors:  Dietrich B Conze; Lori Albert; David A Ferrick; David V Goeddel; Wen-Chen Yeh; Tak Mak; Jonathan D Ashwell
Journal:  Mol Cell Biol       Date:  2005-04       Impact factor: 4.272

3.  Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation.

Authors:  M Holcik; R G Korneluk
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

4.  Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.

Authors:  Damiano Conte; Martin Holcik; Charles A Lefebvre; Eric Lacasse; David J Picketts; Kathryn E Wright; Robert G Korneluk
Journal:  Mol Cell Biol       Date:  2006-01       Impact factor: 4.272

5.  IAPs limit activation of RIP kinases by TNF receptor 1 during development.

Authors:  Maryline Moulin; Holly Anderton; Anne K Voss; Tim Thomas; Wendy Wei-Lynn Wong; Aleksandra Bankovacki; Rebecca Feltham; Diep Chau; Wendy D Cook; John Silke; David L Vaux
Journal:  EMBO J       Date:  2012-02-10       Impact factor: 11.598

6.  Global proteomic analysis of plasma from mice infected with Plasmodium berghei ANKA using two dimensional gel electrophoresis and matrix assisted laser desorption ionization-time of flight mass spectrometry.

Authors:  Evelyn N Gitau; Gilbert O Kokwaro; Charles Rjc Newton; Stephen A Ward
Journal:  Malar J       Date:  2011-07-26       Impact factor: 2.979

7.  Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes.

Authors:  Martin Holcik; Charles A Lefebvre; Keiko Hicks; Robert G Korneluk
Journal:  BMC Genomics       Date:  2002-02-11       Impact factor: 3.969
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.