Literature DB >> 944134

Inhibition of naloxone-induced withdrawal in morphine dependent mice by 1-trans-delta9-tetrahydrocannabinol.

H N Bhargava.   

Abstract

The effects of various doses of 1-trans-delta9-tetrahydrocannabinol (delta9-THC) on naloxone-induced withdrawal were studied in mice rendered dependent on morphine by the pellet implantation procedure. When administered i.p., 30 min prior to naloxone, delta9-THC, inhibited the naloxone-induced withdrawal jumping response. Two other signs of morphine withdrawal (defecation and rearing behavior) were also suppressed by deltapTHC. It is suggested that delta9-THC or some of its derivatives may have potential use in narcotic detoxification.

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Year:  1976        PMID： 944134     DOI： 10.1016/0014-2999(76)90283-1

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Interaction between delta 9-tetrahydrocannabinol and morphine on the motor activity of mice.

Authors:  I H Ayhan; S Kaymakçalan; F C Tulunay
Journal:  Psychopharmacology (Berl)       Date:  1979-05-25       Impact factor: 4.530

2.  Stimulus effects of delta(9)-THC and its interaction with naltrexone and catecholamine blockers in rats.

Authors:  T U Järbe; G C Ohlin
Journal:  Psychopharmacology (Berl)       Date:  1977-10-20       Impact factor: 4.530

3.  Possible mediation of catecholaminergic pathways in the antinociceptive effect of an extract of Cannabis sativa L.

Authors:  S Ferri; E Cavicchini; P Romualdi; E Speroni; G Murari
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Naloxone-induced or postwithdrawal abstinence signs in delta9-tetrahydrocannabinol-tolerant rats.

Authors:  S Kaymakçalan; I H Ayhan; F C Tulunay
Journal:  Psychopharmacology (Berl)       Date:  1977-12-28       Impact factor: 4.530

5.  Therapeutic potential of opioid/cannabinoid combinations in humans: Review of the evidence.

Authors:  Shanna Babalonis; Sharon L Walsh
Journal:  Eur Neuropsychopharmacol       Date:  2020-04-06       Impact factor: 4.600

6.  Effect of delta 9-tetrahydrocannabinol on the morphine-induced hyperactivity of mice.

Authors:  E Ulkü; I H Ayhan; F C Tulunay; B Uran; S Kaymakçalan
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

Review 7.  Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence.

Authors:  Kelly E Dunn; Andrew S Huhn; Cecilia L Bergeria; Cassandra D Gipson; Elise M Weerts
Journal:  J Pharmacol Exp Ther       Date:  2019-08-07       Impact factor: 4.030

8.  CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats.

Authors:  Kiri L Wills; Kiran Vemuri; Alana Kalmar; Alan Lee; Cheryl L Limebeer; Alexandros Makriyannis; Linda A Parker
Journal:  Psychopharmacology (Berl)       Date:  2014-04-27       Impact factor: 4.530

9.  Effect of some cannabinoids on naloxone-precipitated abstinence in morphine-dependent mice.

Authors:  H N Bhargava
Journal:  Psychopharmacology (Berl)       Date:  1976-09-29       Impact factor: 4.530

10.  The effects of morphine and delta-9-tetrahydrocannabinol on motor activity in rats.

Authors:  F C Tulunay; I H Ayhan; S B Sparber
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530
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