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Literature DB >> 6296906

The effects of morphine and delta-9-tetrahydrocannabinol on motor activity in rats.

Abstract

Acute treatment of rats either by high doses of morphine or delta 9-tetrahydrocannabinol (THC) decreased locomotor activity. Naloxone reversed morphine-induced depression completely and reversed THC-induced depression only partially. On day 3 of treatment, tolerance developed to the locomotor inhibitory action of THC or morphine and partial cross-tolerance was observed to the depressant action of THC. Naloxone slightly depressed locomotor activity in THC-tolerant rats, but increased motor activity in morphine-tolerant rats.

Entities: Chemical Disease Species

Mesh：

Substances：
Morphine
Dronabinol

Year: 1982 PMID： 6296906 DOI： 10.1007/bf00433741

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

18 in total

1. Morphine-dependent rats: blockade of precipitated abstinence by tetrahydrocannabinol.

Authors: B Hine; E Friedman; M Torrelio; S Gershon
Journal: Science Date: 1975-02-07 Impact factor: 47.728

2. Tolerance to the effect of delta9-tetrahydrocannabinol in mice on intestinal motility, temperature and locomotor activity.

Authors: P F Anderson; D M Jackson; G B Chesher; R Malor
Journal: Psychopharmacologia Date: 1975-07-23

3. Naloxone-induced or postwithdrawal abstinence signs in delta9-tetrahydrocannabinol-tolerant rats.

Authors: S Kaymakçalan; I H Ayhan; F C Tulunay
Journal: Psychopharmacology (Berl) Date: 1977-12-28 Impact factor: 4.530

4. Behavioral effects of separate and combined administration of naloxone and d-amphetamine.

Authors: S G Holtzman
Journal: J Pharmacol Exp Ther Date: 1974-04 Impact factor: 4.030

Review 5. Interactions of active constituents of marihuana with other drugs in the neuron.

Authors: W L Dewey; K M Johnson; A S Bloom
Journal: Ann N Y Acad Sci Date: 1976 Impact factor: 5.691

6. Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC.

Authors: B Hine; M Torrelio; S Gershon
Journal: Psychopharmacol Commun Date: 1975

7. Comparative analgesic activity of various naturally occurring cannabinoids in mice and rats.

Authors: R D Sofia; H B Vassar; L C Knobloch
Journal: Psychopharmacologia Date: 1975

8. 1-delta9-tetrahydrocannabinol: neurochemical and behavioral effects in the mouse.

Authors: D Holtzman; R A Lovell; J H Jaffe; D X Freedman
Journal: Science Date: 1969-03-28 Impact factor: 47.728

9. Antagonism by chlornaltrexamine of some effects of delta 9-tetrahydrocannabinol in rats.

Authors: F C Tulunay; I H Ayhan; P S Portoghese; A E Takemori
Journal: Eur J Pharmacol Date: 1981-03-12 Impact factor: 4.432

10. A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.

Authors: V F Gellert; S B Sparber
Journal: J Pharmacol Exp Ther Date: 1977-04 Impact factor: 4.030

4 in total

1. Physiological and behavioural effects of the endogenous cannabinoid, arachidonylethanolamide (anandamide), in the rat.

Authors: E A Stein; S A Fuller; W S Edgemond; W B Campbell
Journal: Br J Pharmacol Date: 1996-09 Impact factor: 8.739