Literature DB >> 943846

Hemoglobin synthesis in somatic cell hybrids: independent segregation of the human alpha- and beta-globin genes.

A Deisseroth, R Velez, A W Nienhuis.   

Abstract

Hybrid somatic cells containing a partial complement of human chromosomes were used to demonstrate that the human alpha- and beta-globin genes are located on different chromosomes. Two cell lines consisting of a cross of mouse with human fibroblasts contained the human alpha- and not the beta-globin gene, while a cross of human marrow cells with mouse erythroleukemia cells expressed the human beta- but not the alpha-globin gene.

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Year:  1976        PMID： 943846     DOI： 10.1126/science.943846

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Study of markers of human erythroid differentiation in hybrid cells.

Authors:  A Deisseroth; A Nienhuis
Journal:  In Vitro       Date:  1976-11

2.  Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammals.

Authors:  Juan C Opazo; Federico G Hoffmann; Jay F Storz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-23       Impact factor: 11.205

3.  Adult and fetal human globin genes are expressed following chromosomal transfer into MEL cells.

Authors:  T H Papayannopoulou; D Lindsley; S Kurachi; K Lewison; T Hemenway; M Melis; N P Anagnou; V Najfeld
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

4.  Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis.

Authors:  R V Lebo; A V Carrano; K Burkhart-Schultz; A M Dozy; L C Yu; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

Review 5.  Differentiation of murine erythroleukemic (Friend) cells: an in vitro model of erythropoiesis.

Authors:  S H Orkin
Journal:  In Vitro       Date:  1978-01

6.  Activation of phenotypic expression of human globin genes from nonerythroid cells by chromosome-dependent transfer to tetraploid mouse erythroleukemia cells.

Authors:  A Deisseroth; D Hendrick
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

7.  Negative control of hemoglobin production in somatic cell hybrids due to heme deficiency.

Authors:  S Benoff; S A Bruce; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

8.  The genetic relationship between the tomato mutants, flacca and lateral suppressor, with reference to abscisic acid accumulation.

Authors:  I B Taylor; S Rossall
Journal:  Planta       Date:  1982-03       Impact factor: 4.116
  8 in total

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