BACKGROUND: Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However to date in vivo animal studies have failed to show conclusive results. METHODS: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. RESULTS: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. CONCLUSIONS: Butyrate may inhibit the growth of tumors induced by DMH.
BACKGROUND:Butyric acid is one of the most important by-products of dietary fiber degradation. It is an important trophic agent for the intestinal mucosa under different experimental conditions. Data obtained from several in vitro studies strongly suggest that butyrate can be a potential therapeutic agent in controlling the growth of some cancer cells. However to date in vivo animal studies have failed to show conclusive results. METHODS: We evaluated the effects of intracecal administration of butyrate in an experimental model of colonic carcinogenesis induced by 1,2-dimethylhydrazine (DMH), administered at the site where it is naturally produced, the cecum. We studied the incidence of colon tumors and their main histologic features. RESULTS: Direct application of sodium butyrate significantly decreased the total number of tumors and the incidence of malignancies and carcinoma in the colon. CONCLUSIONS:Butyrate may inhibit the growth of tumors induced by DMH.
Authors: Jacinta Serpa; Francisco Caiado; Tânia Carvalho; Cheila Torre; Luís G Gonçalves; Cristina Casalou; Pedro Lamosa; Margarida Rodrigues; Zhenping Zhu; Eric W F Lam; Sérgio Dias Journal: J Biol Chem Date: 2010-10-06 Impact factor: 5.157
Authors: Mònica Comalada; Elvira Bailón; Oscar de Haro; Federico Lara-Villoslada; Jordi Xaus; Antonio Zarzuelo; Julio Gálvez Journal: J Cancer Res Clin Oncol Date: 2006-05-17 Impact factor: 4.553
Authors: M G Ramos; E A Bambirra; J R Nicoli; D C Cara; E C Vieira; J Alvarez-Leite Journal: Antimicrob Agents Chemother Date: 1999-04 Impact factor: 5.191