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Literature DB >> 9429842

The role of kinins in the antihypertensive and cardioprotective effects of ACE inhibitors.

Abstract

Kinins are highly potent vasoactive peptides. They reduce blood pressure by vasodilation and are cardio- and vasoprotective. ACE inhibitors potentiate the actions of endogenous kinins by about 50-fold. Kinins are involved in the blood pressure-lowering effects of ACE inhibitors in all forms of hypertension associated with stimulation of the renin-angiotensin system. In addition, kinins play an important role in the metabolic, and cardio- and vasoprotective effects of ACE inhibitors.

Entities: Disease Gene

Mesh：

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Year: 1997 PMID： 9429842 DOI： 10.2165/00003495-199700545-00005

Source DB: PubMed Journal: Drugs ISSN： 0012-6667 Impact factor: 9.546

26 in total

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Journal: J Cardiovasc Pharmacol Date: 1986 Jul-Aug Impact factor: 3.105

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Journal: Circ Res Date: 1983-06 Impact factor: 17.367

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Journal: Hypertension Date: 1983 Mar-Apr Impact factor: 10.190

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Journal: Hypertension Date: 1981 Jan-Feb Impact factor: 10.190

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Journal: Circ Res Date: 1982-09 Impact factor: 17.367

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Journal: Klin Wochenschr Date: 1978-04-01

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9. Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist.

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Journal: Br J Clin Pharmacol Date: 1994-10 Impact factor: 4.335