| Literature DB >> 9427640 |
Abstract
Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.Entities:
Mesh:
Substances:
Year: 1998 PMID: 9427640 DOI: 10.1016/s0960-9822(98)70032-6
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834