BACKGROUND/AIMS: Gastric cancer in the young is relatively uncommon, but it carries important clinical significance. This study was designed to determine the clinicopathological characteristics of young patients who underwent a gastrectomy for gastric cancer in order to improve clinical management. METHODOLOGY: From January 1977 to December 1994, 997 patients underwent surgical treatment for gastric cancer in the Department of Surgery of the National Taiwan University Hospital. All of these patients were classified into 6 groups based on their age at the time of surgery. Of these, 52 patients (5.2%) were 35 years of age or younger. The clinicopathological data of these patients were reviewed and compared to the data of the other age groups. RESULTS: There was a female predominance, with a male:female ratio of 1:1.36. In the majority of patients, the time period from the onset of symptoms to the time of diagnosis was less than one year (76.9%). Epigastralgia was the most common complaint (65.4%). Six patients (11%) were diagnosed as having a benign peptic ulcer during the first endoscopy. Histologically, there were more diffuse (65.4%) and scirrhous types of gastric cancer in the young group. Half of the patients (49.9%) were at TNM stage III or IV at the time of surgery. Curative resections were performed on 49 patients. The cumulative 5-year survival rate was 36.1% among the young patients, which was no different from the survival rates of the other age groups. While the 5-year survival rate of patients with stage I gastric cancer was 90% in the young age group, of the 26 patients with stage III or IV, only one survived more than 5 years. Four female patients (13.3%) were found to have metastases to the ovaries during follow-up. CONCLUSION: The clinicopathological characteristics of young patients with gastric cancer are as follows: 1) female dominance; 2) more diffuse and scirrhous types of gastric carcinoma; 3) the prognosis after surgery depends on the stage rather than the age; 4) free use of endoscopy and clinical alertness are important for the early diagnosis of malignancy in young patients.
BACKGROUND/AIMS: Gastric cancer in the young is relatively uncommon, but it carries important clinical significance. This study was designed to determine the clinicopathological characteristics of young patients who underwent a gastrectomy for gastric cancer in order to improve clinical management. METHODOLOGY: From January 1977 to December 1994, 997 patients underwent surgical treatment for gastric cancer in the Department of Surgery of the National Taiwan University Hospital. All of these patients were classified into 6 groups based on their age at the time of surgery. Of these, 52 patients (5.2%) were 35 years of age or younger. The clinicopathological data of these patients were reviewed and compared to the data of the other age groups. RESULTS: There was a female predominance, with a male:female ratio of 1:1.36. In the majority of patients, the time period from the onset of symptoms to the time of diagnosis was less than one year (76.9%). Epigastralgia was the most common complaint (65.4%). Six patients (11%) were diagnosed as having a benign peptic ulcer during the first endoscopy. Histologically, there were more diffuse (65.4%) and scirrhous types of gastric cancer in the young group. Half of the patients (49.9%) were at TNM stage III or IV at the time of surgery. Curative resections were performed on 49 patients. The cumulative 5-year survival rate was 36.1% among the young patients, which was no different from the survival rates of the other age groups. While the 5-year survival rate of patients with stage I gastric cancer was 90% in the young age group, of the 26 patients with stage III or IV, only one survived more than 5 years. Four female patients (13.3%) were found to have metastases to the ovaries during follow-up. CONCLUSION: The clinicopathological characteristics of young patients with gastric cancer are as follows: 1) female dominance; 2) more diffuse and scirrhous types of gastric carcinoma; 3) the prognosis after surgery depends on the stage rather than the age; 4) free use of endoscopy and clinical alertness are important for the early diagnosis of malignancy in young patients.
Authors: Alexander R Novotny; Christoph Schuhmacher; Raymonde Busch; Michael W Kattan; Murray F Brennan; Jörg Rüdiger Siewert Journal: Ann Surg Date: 2006-01 Impact factor: 12.969
Authors: Sara Fill; Andrei Taran; Hans-Ulrich Schulz; Stefan Kahl; Thomas Kalinski; Bobbie Smith; Serban-Dan Costa Journal: World J Gastroenterol Date: 2008-02-14 Impact factor: 5.742
Authors: Horacio Noé López-Basave; Flavia Morales-Vásquez; Juan Manuel Ruiz-Molina; Silvio A Namendys-Silva; Itzel Vela-Sarmiento; Javier Melchor Ruan; Alejandro E Padilla Rosciano; German Calderillo-Ruiz; Consuelo Díaz-Romero; Angel Herrera-Gómez; Abelardo A Meneses-García Journal: Cancer Manag Res Date: 2013-04-04 Impact factor: 3.989