| Literature DB >> 9425738 |
Abstract
Recent data have indicated that the major histocompatibility complex (MHC) class I-related receptor FcRn plays a role in regulating serum IgG levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta suggests that the studies in rodents have relevance to understanding similar processes in humans. This has implications for the engineering of improved antibodies for therapy.Entities:
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Year: 1997 PMID： 9425738 DOI： 10.1016/s0167-5699(97)01172-9
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699