Literature DB >> 9423884

Immunization of Aotus monkeys with recombinant Plasmodium falciparum hybrid proteins does not reproducibly result in protection from malaria infection.

C H Kocken1, E Hundt, B Knapp, D Brazel, B Enders, D L Narum, J A Wubben, A W Thomas.   

Abstract

Plasmodium falciparum antigens SERP, HRPII, MSAI, and 41-3 have shown promise as vaccine components. This study aimed at reproducing and extending previous results using three hybrid molecules. Antibody responses were reproduced in Aotus monkeys, but solid protection from a P. falciparum blood-stage challenge that showed an unintendedly enhanced pathogenicity was not observed.

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Year:  1998        PMID： 9423884      PMCID： PMC107908     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

1.  Responses of T cells from sensitized donors to recombinant and synthetic peptides corresponding to sequences of the Plasmodium falciparum SERP antigen.

Authors:  C Roussilhon; E Hundt; M Agrapart; W Stüber; B Knapp; P Dubois; J J Ballet
Journal:  Immunol Lett       Date:  1990-08       Impact factor: 3.685

2.  Demonstration of alternative splicing of a pre-mRNA expressed in the blood stage form of Plasmodium falciparum.

Authors:  B Knapp; U Nau; E Hundt; H A Küpper
Journal:  J Biol Chem       Date:  1991-04-15       Impact factor: 5.157

3.  HLA polymorphism and T cell recognition of a conserved region of p190, a malaria vaccine candidate.

Authors:  M Guttinger; P Romagnoli; L Vandel; R Meloen; B Takacs; J R Pink; F Sinigaglia
Journal:  Int Immunol       Date:  1991-09       Impact factor: 4.823

4.  Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA.

Authors:  D J Bzik; W B Li; T Horii; J Inselburg
Journal:  Mol Biochem Parasitol       Date:  1988-09       Impact factor: 1.759

5.  Molecular cloning, genomic structure and localization in a blood stage antigen of Plasmodium falciparum characterized by a serine stretch.

Authors:  B Knapp; E Hundt; U Nau; H A Küpper
Journal:  Mol Biochem Parasitol       Date:  1989-01-01       Impact factor: 1.759

6.  Protection of Aotus monkeys from malaria infection by immunization with recombinant hybrid proteins.

Authors:  B Knapp; E Hundt; B Enders; H A Küpper
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

7.  Homologous genes encode two distinct histidine-rich proteins in a cloned isolate of Plasmodium falciparum.

Authors:  T E Wellems; R J Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

8.  Strategies for the development of an antimalarial vaccine.

Authors:  B Enders; E Hundt; B Knapp
Journal:  Vaccine       Date:  1992       Impact factor: 3.641

9.  Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.

Authors:  A Crisanti; H M Müller; C Hilbich; F Sinigaglia; H Matile; M McKay; J Scaife; K Beyreuther; H Bujard
Journal:  Science       Date:  1988-06-03       Impact factor: 47.728

10.  Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites.

Authors:  A A Holder; M J Lockyer; K G Odink; J S Sandhu; V Riveros-Moreno; S C Nicholls; Y Hillman; L S Davey; M L Tizard; R T Schwarz
Journal:  Nature       Date:  1985 Sep 19-25       Impact factor: 49.962
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  4 in total

1.  Mimotopes of apical membrane antigen 1: Structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue.

Authors:  Jennifer K Sabo; David W Keizer; Zhi-Ping Feng; Joanne L Casey; Kathy Parisi; Andrew M Coley; Michael Foley; Raymond S Norton
Journal:  Infect Immun       Date:  2006-10-23       Impact factor: 3.441

2.  Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope.

Authors:  Sope Olugbile; Viviane Villard; Sylvie Bertholet; Ali Jafarshad; Caroline Kulangara; Christian Roussilhon; Geraldine Frank; George W Agak; Ingrid Felger; Issa Nebie; Karidia Konate; Andrey V Kajava; Peter Schuck; Pierre Druilhe; François Spertini; Giampietro Corradin
Journal:  Vaccine       Date:  2011-07-29       Impact factor: 3.641

3.  Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques.

Authors:  Muzamil Mahdi Abdel Hamid; Edmond J Remarque; Ibrahim M El Hassan; Ayman A Hussain; David L Narum; Alan W Thomas; Clemens H M Kocken; Walter R Weiss; Bart W Faber
Journal:  Malar J       Date:  2011-02-08       Impact factor: 2.979

4.  Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.

Authors:  Priya Pal; Brian P Daniels; Anna Oskman; Michael S Diamond; Robyn S Klein; Daniel E Goldberg
Journal:  MBio       Date:  2016-06-07       Impact factor: 7.867
  4 in total

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