Literature DB >> 2453924

Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum.

A Crisanti1, H M Müller, C Hilbich, F Sinigaglia, H Matile, M McKay, J Scaife, K Beyreuther, H Bujard.   

Abstract

In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different Plasmodium falciparum isolates in culture, showing that the epitopes are recognized in native parasites.

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Year:  1988        PMID： 2453924     DOI： 10.1126/science.2453924

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  17 in total

Review 1.  Where are we in the quest for vaccines for malaria?

Authors:  W A Siddiqui
Journal:  Drugs       Date:  1991-01       Impact factor: 9.546

2.  Vaccine T-cell epitope selection by a peptide competition assay.

Authors:  J Kilgus; P Romagnoli; M Guttinger; D Stuber; L Adorini; F Sinigaglia
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

3.  Protection of Aotus monkeys from malaria infection by immunization with recombinant hybrid proteins.

Authors:  B Knapp; E Hundt; B Enders; H A Küpper
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

4.  Allelic diversity and antibody recognition of Plasmodium falciparum merozoite surface protein 1 during hypoendemic malaria transmission in the Brazilian amazon region.

Authors:  L A Da Silveira; M L Dorta; E A Kimura; A M Katzin; F Kawamoto; K Tanabe; M U Ferreira
Journal:  Infect Immun       Date:  1999-11       Impact factor: 3.441

5.  Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum.

Authors:  P H Jakobsen; L Hviid; T G Theander; E A Afare; R G Ridley; P M Heegaard; D Stuber; K Dalsgaard; F K Nkrumah
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

6.  Human HLA class I- and HLA class II-restricted cloned cytotoxic T lymphocytes identify a cluster of epitopes on the measles virus fusion protein.

Authors:  R S van Binnendijk; J P Versteeg-van Oosten; M C Poelen; H F Brugghe; P Hoogerhout; A D Osterhaus; F G Uytdehaag
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

7.  Generalized immunological recognition of the major merozoite surface antigen (gp195) of Plasmodium falciparum.

Authors:  S P Chang; G S Hui; A Kato; W A Siddiqui
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

8.  Cellular and humoral immune responses to well-defined blood stage antigens (major merozoite surface antigen) of Plasmodium falciparum in adults from an Indian zone where malaria is endemic.

Authors:  L Kabilan; V P Sharma; P Kaur; S K Ghosh; R S Yadav; V S Chauhan
Journal:  Infect Immun       Date:  1994-02       Impact factor: 3.441

9.  Analysis of the human antibody response to thrombospondin-related anonymous protein of Plasmodium falciparum.

Authors:  E Scarselli; R Tolle; O Koita; M Diallo; H M Müller; K Früh; O Doumbo; A Crisanti; H Bujard
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

10.  Conservation of antigen components from two recombinant hybrid proteins protective against malaria.

Authors:  B Knapp; U Nau; E Hundt
Journal:  Infect Immun       Date:  1993-03       Impact factor: 3.441
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