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Literature DB >> 9421

Effect of glass on pH-dependent stability of typhoid vaccine.

Abstract

Vaccines made from the Ty-2 strain of Salmonella typhosa were tested periodically for stability of pH and of potency. The acetone-treated cultures prepared in buffered saline solutions retained potency beyond 30 months of storage at 0 to 5 C. Similar vaccines in unbuffered saline solutions lost potency coincident with increase of alkalinity. Vaccines packaged in United States Pharmacopeia borosilicate glass vials retained potency and pH stability, whereas those in Type III United States Pharmacopeia soda-lime glass vials were less stable.

Entities: Chemical Disease Species

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Year: 1976 PMID： 9421 PMCID： PMC274137

Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948

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References

10 in total

Effect of glass on pH-dependent stability of typhoid vaccine.

1. Studies on Vi antigen. VIII. Role of acetyl in antigenic activity.

2. Studies on Vi antigen. VII. Characteristics of the immune response in the mouse.

3. Duration of potency of T.A.B. vaccine stored at room temperature.

4. The influence of storage on the antibody-stimulating properties of different typhoid vaccines.

5. Enhancement of the immunogenicity of typhoid vaccine by retention of the V1 antigen.

6. Preservation of typhoid vaccine.

7. Effect of a Vi-degrading enzyme on potency of typhoid vaccines in mice.

8. Adhesion of Vi antigen and toxicity in typhoid vaccines inactivated by acetone or by heat and phenol.

Review 9. On vaccines and vaccination: typhoid-paratyphoid fevers.

10. Physiochemical properties of the Vi antigen before and after mild alkaline hydrolysis.