Literature DB >> 9420701

The use of iodinated free fatty acids for assessing fatty acid metabolism.

N Tamaki1, M Kawamoto.   

Abstract

Free fatty acid is a major substrate fuel for normal myocardium. Cardiovascular disease is frequently associated with impairment of fatty acid oxidation. Therefore assessment of fatty acid metabolism may be an important tool for the early detection of myocardial abnormalities and may provide insight into pathologic heart conditions. Although carbon 11-labeled palmitate is a well-established tracer for probing myocardial fatty acid metabolism, a variety of iodinated fatty acid compounds have been introduced for assessing fatty acid metabolism, including straight-chain and branched-chain fatty acid compounds. Straight-chain fatty acid has advantages for measuring fatty acid oxidation on the basis of tracer clearance from the myocardium. Branched-chain fatty acid can be trapped in the myocardium without further washout and uptake in the myocardium may reflect fatty acid retention and some aspect of fatty acid metabolism. A long tracer retention period makes feasible the acquisition of single-photon emission computed tomographic images. This review examines the characteristics of both types of tracers and our recent clinical experience with beta-methyliodophenyl pentadecanoic acid, which has potential for detecting and characterizing both ischemic heart disease and cardiomyopathy.

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Year:  1994        PMID： 9420701     DOI： 10.1007/bf02940072

Source DB:  PubMed          Journal:  J Nucl Cardiol        ISSN： 1071-3581            Impact factor:   5.952


  34 in total

1.  Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S)methylpentadecanoic acid (BMIPP), in relation to ATP concentration.

Authors:  Y Fujibayashi; Y Yonekura; Y Takemura; K Wada; K Matsumoto; N Tamaki; K Yamamoto; J Konishi; A Yokoyama
Journal:  J Nucl Med       Date:  1990-11       Impact factor: 10.057

2.  Regional myocardial blood flow and metabolism at rest in mildly symptomatic patients with hypertrophic cardiomyopathy.

Authors:  M Grover-McKay; M Schwaiger; J Krivokapich; J K Perloff; M E Phelps; H R Schelbert
Journal:  J Am Coll Cardiol       Date:  1989-02       Impact factor: 24.094

Review 3.  Myocardial utilization of carbohydrate and lipids.

Authors:  J R Neely; M J Rovetto; J F Oram
Journal:  Prog Cardiovasc Dis       Date:  1972 Nov-Dec       Impact factor: 8.194

4.  C-11 palmitate for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. IV. In vivo evaluation of acute demand-induced ischemia in dogs.

Authors:  H R Schelbert; E Henze; R Keen; H R Schon; H Hansen; C Selin; S C Huang; J R Barrio; M E Phelps
Journal:  Am Heart J       Date:  1983-10       Impact factor: 4.749

5.  Localization of viable, ischemic myocardium by positron-emission tomography with 11C-palmitate.

Authors:  R A Lerch; H D Ambos; S R Bergmann; M J Welch; M M Ter-Pogossian; B E Sobel
Journal:  Circulation       Date:  1981-10       Impact factor: 29.690

6.  C- 11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. I. Kinetics of C- 11 palmitic acid in normal myocardium.

Authors:  H R Schön; H R Schelbert; G Robinson; A Najafi; S C Huang; H Hansen; J Barrio; D E Kuhl; M E Phelps
Journal:  Am Heart J       Date:  1982-04       Impact factor: 4.749

7.  Myocardial emission computed tomography with iodine-123-labeled beta-methyl-branched fatty acid in patients with hypertrophic cardiomyopathy.

Authors:  C Kurata; K Tawarahara; T Taguchi; S Aoshima; A Kobayashi; N Yamazaki; H Kawai; M Kaneko
Journal:  J Nucl Med       Date:  1992-01       Impact factor: 10.057

8.  The use of 123I-labeled heptadecanoic acid (HDA) as metabolic tracer: preliminary report.

Authors:  R Dudczak; K Kletter; H Frischauf; U Losert; P Angelberger; R Schmoliner
Journal:  Eur J Nucl Med       Date:  1984

9.  15(p-[123I]Iodophenyl)pentadecanoic acid as tracer of lipid metabolism: comparison with [1-14C]palmitic acid in murine tissues.

Authors:  S N Reske; W Sauer; H J Machulla; C Winkler
Journal:  J Nucl Med       Date:  1984-12       Impact factor: 10.057

10.  Dual tracer autoradiographic study of beta-methyl-(1-14C) heptadecanoic acid and 15-p-(131I)-iodophenyl-beta-methylpentadecanoic acid in normotensive and hypertensive rats.

Authors:  K Yamamoto; P Som; A B Brill; Y Yonekura; S C Srivastava; G E Meinken; J Iwai; M M Goodman; F F Knapp; D R Elmaleh
Journal:  J Nucl Med       Date:  1986-07       Impact factor: 10.057
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  4 in total

Review 1.  Future aspects of BMIPP.

Authors:  N Tamaki; K Morita; E Tsukamoto; Y Kawai
Journal:  Int J Card Imaging       Date:  1999-02

Review 2.  Cardiac metabolism: a technical spectrum of modalities including positron emission tomography, single-photon emission computed tomography, and magnetic resonance spectroscopy.

Authors:  R Valkema; B L van Eck-Smit; E E van der Wall
Journal:  J Nucl Cardiol       Date:  1994 Nov-Dec       Impact factor: 5.952

Review 3.  Radionuclide assessment of myocardial fatty acid metabolism by PET and SPECT.

Authors:  N Tamaki; Y Fujibayashi; Y Magata; Y Yonekura; J Konishi
Journal:  J Nucl Cardiol       Date:  1995 May-Jun       Impact factor: 5.952

4.  Prognostic value of iodine-123 labelled BMIPP fatty acid analogue imaging in patients with myocardial infarction.

Authors:  N Tamaki; E Tadamura; T Kudoh; N Hattori; Y Yonekura; R Nohara; S Sasayama; K Ikekubo; H Kato; J Konishi
Journal:  Eur J Nucl Med       Date:  1996-03
  4 in total

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