Literature DB >> 9420228

Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A.

B Ackerson1, O Rey, J Canon, P Krogstad.   

Abstract

Gag polyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the formation of infectious human immunodeficiency virus type 1 (HIV-1) virions. Either a point mutation in Gag (P222A) or drugs which bind CyPA decrease virion incorporation of CyPA and interfere with HIV-1 replication. We have found that lymphoid cells varied greatly in their CyPA content and that cells with high CyPA content supported the replication of P222A HIV-1 Gag mutants. These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur.

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Year:  1998        PMID： 9420228      PMCID： PMC109377     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

1.  The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions.

Authors:  X Yu; X Yuan; Z Matsuda; T H Lee; M Essex
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

2.  Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles.

Authors:  A J Smith; N Srinivasakumar; M L Hammarskjöld; D Rekosh
Journal:  J Virol       Date:  1993-04       Impact factor: 5.103

3.  Assembly, processing, and infectivity of human immunodeficiency virus type 1 gag mutants.

Authors:  C T Wang; E Barklis
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

4.  Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein.

Authors:  T Dorfman; F Mammano; W A Haseltine; H G Göttlinger
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

5.  Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.

Authors:  M I Bukrinsky; N Sharova; T L McDonald; T Pushkarskaya; W G Tarpley; M Stevenson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Nuclear retention of M1 protein in a temperature-sensitive mutant of influenza (A/WSN/33) virus does not affect nuclear export of viral ribonucleoproteins.

Authors:  O Rey; D P Nayak
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

7.  The nonmyristylated Pr160gag-pol polyprotein of human immunodeficiency virus type 1 interacts with Pr55gag and is incorporated into viruslike particles.

Authors:  J Park; C D Morrow
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

8.  Identification of temperature-sensitive mutants of the human immunodeficiency virus type 1 protease through saturation mutagenesis. Amino acid side chain requirements for temperature sensitivity.

Authors:  M Manchester; L Everitt; D D Loeb; C A Hutchison; R Swanstrom
Journal:  J Biol Chem       Date:  1994-03-11       Impact factor: 5.157

9.  Inhibition of human immunodeficiency virus replication by nonimmunosuppressive analogs of cyclosporin A.

Authors:  S R Bartz; E Hohenwalter; M K Hu; D H Rich; M Malkovsky
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-06       Impact factor: 11.205

10.  A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.

Authors:  M I Bukrinsky; S Haggerty; M P Dempsey; N Sharova; A Adzhubel; L Spitz; P Lewis; D Goldfarb; M Emerman; M Stevenson
Journal:  Nature       Date:  1993-10-14       Impact factor: 69.504
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  26 in total

1.  Structural consequences of cyclophilin A binding on maturational refolding in human immunodeficiency virus type 1 capsid protein.

Authors:  L Dietrich; L S Ehrlich; T J LaGrassa; D Ebbets-Reed; C Carter
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

2.  Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells.

Authors:  Neeltje A Kootstra; Carsten Munk; Nina Tonnu; Nathaniel R Landau; Inder M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-23       Impact factor: 11.205

3.  A molecular dynamics study of Cyclophilin A free and in complex with the Ala-Pro dipeptide.

Authors:  Pekka Mark; Lennart Nilsson
Journal:  Eur Biophys J       Date:  2007-01-16       Impact factor: 1.733

4.  Cryoelectron microscopic examination of human immunodeficiency virus type 1 virions with mutations in the cyclophilin A binding loop.

Authors:  L B Kong; D An; B Ackerson; J Canon; O Rey; I S Chen; P Krogstad; P L Stewart
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

5.  Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity.

Authors:  Natalie N Kinloch; Guinevere Q Lee; Jonathan M Carlson; Steven W Jin; Chanson J Brumme; Helen Byakwaga; Conrad Muzoora; Mwebesa B Bwana; Kyle D Cobarrubias; Peter W Hunt; Jeff N Martin; Mary Carrington; David R Bangsberg; P Richard Harrigan; Mark A Brockman; Zabrina L Brumme
Journal:  J Virol       Date:  2018-12-10       Impact factor: 5.103

6.  Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.

Authors:  Theodora Hatziioannou; David Perez-Caballero; Simone Cowan; Paul D Bieniasz
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

7.  A restriction enzyme based cloning method to assess the in vitro replication capacity of HIV-1 subtype C Gag-MJ4 chimeric viruses.

Authors:  Daniel T Claiborne; Jessica L Prince; Eric Hunter
Journal:  J Vis Exp       Date:  2014-08-31       Impact factor: 1.355

8.  Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant.

Authors:  Chisu Song; Christopher Aiken
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

9.  Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A.

Authors:  Songkai Liu; Maria Asparuhova; Vincent Brondani; Ingrid Ziekau; Thomas Klimkait; Daniel Schümperli
Journal:  Nucleic Acids Res       Date:  2004-07-14       Impact factor: 16.971

10.  Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity.

Authors:  C Aiken
Journal:  Virology       Date:  1998-08-15       Impact factor: 3.616
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