RATIONALE AND OBJECTIVES: We obtained image contrast in pathologic specimens without the use of contrast material by using phase-contrast imaging with synchrotron X-rays. METHODS: An experiment was performed at the three-pole superconducting vertical wiggler beam line BL-14B at the Photon Factory in Tsukuba, Japan. The X-ray phase-contrast imaging system consisted of a double crystal monochromator, an asymmetrically cut crystal monochromator, a triple Laue-case X-ray interferometer, and film. The pathologic specimen was a sample from human liver that had metastatic carcinoma. RESULTS: The X-ray phase-contrast images of the pathologic specimen clearly depicted the cancerous lesion without the use of contrast enhancement, and the image showed good correlation with the photograph of the specimen. The X-ray absorption image did not differentiate between the normal liver tissue and the tumor. CONCLUSION: The results of this preliminary experiment reveal that for materials such as biologic specimens with a low atomic number, X-ray phase-contrast imaging better differentiates tissues than does the absorption contrast imaging commonly used in radiology.
RATIONALE AND OBJECTIVES: We obtained image contrast in pathologic specimens without the use of contrast material by using phase-contrast imaging with synchrotron X-rays. METHODS: An experiment was performed at the three-pole superconducting vertical wiggler beam line BL-14B at the Photon Factory in Tsukuba, Japan. The X-ray phase-contrast imaging system consisted of a double crystal monochromator, an asymmetrically cut crystal monochromator, a triple Laue-case X-ray interferometer, and film. The pathologic specimen was a sample from human liver that had metastatic carcinoma. RESULTS: The X-ray phase-contrast images of the pathologic specimen clearly depicted the cancerous lesion without the use of contrast enhancement, and the image showed good correlation with the photograph of the specimen. The X-ray absorption image did not differentiate between the normal liver tissue and the tumor. CONCLUSION: The results of this preliminary experiment reveal that for materials such as biologic specimens with a low atomic number, X-ray phase-contrast imaging better differentiates tissues than does the absorption contrast imaging commonly used in radiology.
Authors: Mahesh B Nagarajan; Paola Coan; Markus B Huber; Paul C Diemoz; Christian Glaser; Axel Wismüller Journal: J Digit Imaging Date: 2014-02 Impact factor: 4.056
Authors: Anas Z Abidin; Botao Deng; Adora M DSouza; Mahesh B Nagarajan; Paola Coan; Axel Wismüller Journal: Comput Biol Med Date: 2018-02-09 Impact factor: 4.589
Authors: Mahesh B Nagarajan; Paola Coan; Markus B Huber; Paul C Diemoz; Axel Wismüller Journal: Med Biol Eng Comput Date: 2015-07-04 Impact factor: 2.602
Authors: Mahesh B Nagarajan; Paola Coan; Markus B Huber; Paul C Diemoz; Christian Glaser; Axel Wismuller Journal: IEEE Trans Biomed Eng Date: 2013-06-05 Impact factor: 4.538
Authors: Sarina Wan; Benedicta D Arhatari; Yakov I Nesterets; Sheridan C Mayo; Darren Thompson; Jane Fox; Beena Kumar; Zdenka Prodanovic; Daniel Hausermann; Anton Maksimenko; Christopher Hall; Matthew Dimmock; Konstantin M Pavlov; Darren Lockie; Mary Rickard; Ziba Gadomkar; Alaleh Aminzadeh; Elham Vafa; Andrew Peele; Harry M Quiney; Sarah Lewis; Timur E Gureyev; Patrick C Brennan; Seyedamir Tavakoli Taba Journal: J Med Imaging (Bellingham) Date: 2021-07-12