| Literature DB >> 9417033 |
Abstract
Sites of DNA synthesis initiation have been detected at the nucleotide level in a yeast origin of bidirectional replication with the use of replication initiation point mapping. The ARS1 origin of Saccharomyces cerevisiae showed a transition from discontinuous to continuous DNA synthesis in an 18-base pair region (nucleotides 828 to 845) from within element B1 toward B2, adjacent to the binding site for the origin recognition complex, the putative initiator protein.Entities:
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Year: 1998 PMID: 9417033 DOI: 10.1126/science.279.5347.95
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728