Literature DB >> 9415147

Hemoglobin and free radicals: implications for the development of a safe blood substitute.

A I Alayash1, R E Cashon.   

Abstract

The two major concerns in the development of cell-free hemoglobin as a blood substitute (i.e. circulatory retention and oxygen delivery) have been resolved successfully by strategic chemical or genetic modification of the protein. However, the redox reactivity of hemoglobin and its impact on the physiological processes has not been fully understood, nor has it been subject to control by design. This article reviews current research into heme-mediated toxicities that potentially constitute serious impediments to the development of a usable blood substitute.

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Year:  1995        PMID： 9415147     DOI： 10.1016/s1357-4310(95)80089-1

Source DB:  PubMed          Journal:  Mol Med Today        ISSN： 1357-4310


  9 in total

1.  The oxyhemoglobin reaction of nitric oxide.

Authors:  A J Gow; B P Luchsinger; J R Pawloski; D J Singel; J S Stamler
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

2.  Hemoglobin-dialdehyde dextran conjugates: improvement of their oxygen-binding properties with anionic groups.

Authors:  F Bonneaux; E Dellacherie; P Labrude; C Vigneron
Journal:  J Protein Chem       Date:  1996-07

Review 3.  Intravascular hemolysis and the pathophysiology of sickle cell disease.

Authors:  Gregory J Kato; Martin H Steinberg; Mark T Gladwin
Journal:  J Clin Invest       Date:  2017-03-01       Impact factor: 14.808

4.  In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.

Authors:  Dong Wang; Barbora Piknova; Steven B Solomon; Irene Cortes-Puch; Steven J Kern; Junfeng Sun; Tamir Kanias; Mark T Gladwin; Christine Helms; Daniel B Kim-Shapiro; Alan N Schechter; Charles Natanson
Journal:  Transfusion       Date:  2013-03-14       Impact factor: 3.157

Review 5.  βCysteine 93 in human hemoglobin: a gateway to oxidative stability in health and disease.

Authors:  Abdu I Alayash
Journal:  Lab Invest       Date:  2020-09-26       Impact factor: 5.662

6.  Coexpression of human alpha- and circularly permuted beta-globins yields a hemoglobin with normal R state but modified T state properties.

Authors:  Anna L Asmundson; Alexandria M Taber; Adella van der Walde; Danielle H Lin; John S Olson; Spencer J Anthony-Cahill
Journal:  Biochemistry       Date:  2009-06-16       Impact factor: 3.162

Review 7.  Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Authors:  Abdu I Alayash
Journal:  Biomolecules       Date:  2017-01-04

8.  The Antibacterial Activity of Erythrocytes From Goose (Anser domesticus) Can Be Associated With Phagocytosis and Respiratory Burst Generation.

Authors:  Youcheng Yang; Jiajun Chen; Linqing Lu; Zizheng Xu; Feng Li; Minxuan Yang; Jun Li; Li Lin; Zhendong Qin
Journal:  Front Immunol       Date:  2022-01-13       Impact factor: 7.561

9.  Mechanisms of Toxicity and Modulation of Hemoglobin-based Oxygen Carriers.

Authors:  Abdu I Alayash
Journal:  Shock       Date:  2019-10       Impact factor: 3.454
  9 in total

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