Literature DB >> 941020

Side chain metabolism of 25-hydroxy-[26,27-14C] vitamin D3 and 1,25-dihydroxy-[26,27-14C] vitamin D3 in vivo.

D Harnden, R Kumar, M F Holick, H F Deluca.   

Abstract

Radioactive CO2 was detected in expired air after the administration of 25-hydroxy-[26,27-14C] vitamin d3 to vitamin D-deficient hypocalcemic rats; 14co2 was also detected after the administration of 1,25-dihydroxy-[26,27-14C] vitamin D3 to rats raised on the same diet. Nephretcomy totally abolished 14CO2 formation after administration of 25-hydroxy-[26,27-14C] vitamin D3 but not after the administration of 1,25-dihydroxy-[26,27-14C] vitamin D3. The production of 14CO2 commenced within 4 hours after injection of 1,25-dihydroxy-[26,27-14C] vitamin D3, suggesting a possible relevance of this reaction to the function of 1,25-dihydroxyvitamin D3. These results at least demonstrate a new metabolic pathway of vitamin D3 metabolism involving the oxidation of a portion of the side chain of 1,25-dihydroxyvitamin D3 to CO2.

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Year:  1976        PMID： 941020     DOI： 10.1126/science.941020

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation.

Authors:  G Makin; D Lohnes; V Byford; R Ray; G Jones
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

2.  Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone.

Authors:  David E Prosser; Martin Kaufmann; Brendan O'Leary; Valarie Byford; Glenville Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-23       Impact factor: 11.205

Review 3.  Vitamin D-endocrine system.

Authors:  N H Bell
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

Review 4.  Vitamin D and the kidney.

Authors:  Rajiv Kumar; Peter J Tebben; James R Thompson
Journal:  Arch Biochem Biophys       Date:  2012-03-15       Impact factor: 4.013

Review 5.  Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment.

Authors:  Peter J Tebben; Ravinder J Singh; Rajiv Kumar
Journal:  Endocr Rev       Date:  2016-09-02       Impact factor: 19.871

6.  Enhanced sensitivity of young suckling rats to the toxic effects of 1,25-dihydroxyvitamin D3.

Authors:  L A Dostal; S U Toverud
Journal:  Calcif Tissue Int       Date:  1983-07       Impact factor: 4.333

7.  Enterohepatic physiology of 1,25-dihydroxyvitamin D3.

Authors:  R Kumar; S Nagubandi; V R Mattox; J M Londowski
Journal:  J Clin Invest       Date:  1980-02       Impact factor: 14.808

8.  A novel development indicator based on population-average height trajectories of children aged 0-5 years modelled using 145 surveys in 64 countries, 2000-2018.

Authors:  Eric O Ohuma; Diego G Bassani; Huma Qamar; Seungmi Yang; Daniel E Roth
Journal:  BMJ Glob Health       Date:  2021-03
  8 in total

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