Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation.

Literature DB >> 2818561

Target cell metabolism of 1,25-dihydroxyvitamin D3 to calcitroic acid. Evidence for a pathway in kidney and bone involving 24-oxidation.

G Makin¹, D Lohnes, V Byford, R Ray, G Jones.

Abstract

1,25-dihydroxyvitamin D3 is converted to calcitroic acid before being excreted in the bile. Biosynthesis of calcitroic acid has been demonstrated in two target cells of vitamin D, in the kidney and the osteoblastic cell line UMR-106. Calcitroic acid was identified by combinations of h.p.l.c., u.v. spectroscopy and mass spectrometry. Evidence is presented that calcitroate is derived from the 24-oxidation pathway, possibly through the intermediate 24,25,26,27-tetranor-1,23-dihydroxyvitamin D3. The 24-oxidation pathway to calcitroic acid in bone cells is stimulated by 1,25-dihydroxyvitamin D3. The pathway in both bone cells and perfused kidney operates at physiological concentrations of substrate and appears to be capable of rapid clearance of the hormone.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2818561 PMCID： PMC1133244 DOI： 10.1042/bj2620173

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

28 in total

1. A rapid method of total lipid extraction and purification.

Authors: E G BLIGH; W J DYER
Journal: Can J Biochem Physiol Date: 1959-08

2. Side chain metabolism of 25-hydroxy-[26,27-14C] vitamin D3 and 1,25-dihydroxy-[26,27-14C] vitamin D3 in vivo.

Authors: D Harnden; R Kumar; M F Holick; H F Deluca
Journal: Science Date: 1976-08-06 Impact factor: 47.728

3. Unique biosynthesis by kidney of a biological active vitamin D metabolite.

Authors: D R Fraser; E Kodicek
Journal: Nature Date: 1970-11-21 Impact factor: 49.962

4. Calcitroic acid: biological activity and tissue distribution studies.

Authors: R P Esvelt; H F De Luca
Journal: Arch Biochem Biophys Date: 1981-02 Impact factor: 4.013

5. Receptors for 1,25(OH)2-vitamin D3 enriched in cloned osteoblast-like rat osteogenic sarcoma cells.

Authors: N C Partridge; R J Frampton; J A Eisman; V P Michelangeli; E Elms; T R Bradley; T J Martin
Journal: FEBS Lett Date: 1980-06-16 Impact factor: 4.124

6. 24,24-difluoro-1,25-dihydroxyvitamin D3: in vitro production, isolation, and biological activity.

Authors: Y Tanaka; H F Deluca; H K Schnoes; N Ikekawa; Y Kobayashi
Journal: Arch Biochem Biophys Date: 1980-02 Impact factor: 4.013

7. 25-hydroxyvitamin D3 metabolism by isolated perfused rat kidney.

Authors: A M Rosenthal; G Jones; S W Kooh; D Fraser
Journal: Am J Physiol Date: 1980-07

8. Chemical synthesis of [1 beta-3H] 1 alpha, 25-dihydroxyvitamin D3 and [1 alpha-3H] 1 beta, 25-dihydroxyvitamin D2: biological activity of 1 beta, 25-dihydroxyvitamin D3.

Authors: S A Holick; M F Holick; J A MacLaughlin
Journal: Biochem Biophys Res Commun Date: 1980-12-16 Impact factor: 3.575

9. Isolation and characterization of 1 alpha-hydroxy-23-carboxytetranorvitamin D: a major metabolite of 1,25-dihydroxyvitamin D3.

Authors: R P Esvelt; H K Schnoes; H F DeLuca
Journal: Biochemistry Date: 1979-09-04 Impact factor: 3.162

10. 1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.

Authors: P A Price; S A Baukol
Journal: J Biol Chem Date: 1980-12-25 Impact factor: 5.157

31 in total

1. Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.

Authors: Wei Luo; Adam R Karpf; Kristin K Deeb; Josephia R Muindi; Carl D Morrison; Candace S Johnson; Donald L Trump
Journal: Cancer Res Date: 2010-06-29 Impact factor: 12.701

2. Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.

Authors: Elaine W Tieu; Wei Li; Jianjun Chen; Tae-Kang Kim; Dejian Ma; Andrzej T Slominski; Robert C Tuckey
Journal: J Steroid Biochem Mol Biol Date: 2015-02-26 Impact factor: 4.292

3. Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone.

Authors: David E Prosser; Martin Kaufmann; Brendan O'Leary; Valarie Byford; Glenville Jones
Journal: Proc Natl Acad Sci U S A Date: 2007-07-23 Impact factor: 11.205

Review 4. Effect of nutritional vitamin D preparations on parathyroid hormone in patients with chronic kidney disease.

Authors: Chrysoula Pipili; Chrysostomos Dimitriadis; Nigar Sekercioglu; Joanne M Bargman; Dimitrios D Oreopoulos
Journal: Int Urol Nephrol Date: 2011-08-26 Impact factor: 2.370

Review 5. Formation and Cleavage of C-C Bonds by Enzymatic Oxidation-Reduction Reactions.

Authors: F Peter Guengerich; Francis K Yoshimoto
Journal: Chem Rev Date: 2018-06-22 Impact factor: 60.622

Review 6. Cytochrome P450-mediated metabolism of vitamin D.

Authors: Glenville Jones; David E Prosser; Martin Kaufmann
Journal: J Lipid Res Date: 2013-04-06 Impact factor: 5.922

Review 7. Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis.

Authors: Wei Zhen Yeh; Melissa Gresle; Vilija Jokubaitis; Jim Stankovich; Anneke van der Walt; Helmut Butzkueven
Journal: Br J Pharmacol Date: 2020-08-05 Impact factor: 8.739

Review 8. Calcitroic Acid-A Review.

Authors: Olivia B Yu; Leggy A Arnold
Journal: ACS Chem Biol Date: 2016-09-06 Impact factor: 5.100

9. 1 alpha,24(S)-dihydroxyvitamin D2: a biologically active product of 1 alpha-hydroxyvitamin D2 made in the human hepatoma, Hep3B.

Authors: S Strugnell; V Byford; H L Makin; R M Moriarty; R Gilardi; L W LeVan; J C Knutson; C W Bishop; G Jones
Journal: Biochem J Date: 1995-08-15 Impact factor: 3.857

10. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface.

Authors: Boris Novakovic; Mandy Sibson; Hong Kiat Ng; Ursula Manuelpillai; Vardhman Rakyan; Thomas Down; Stephan Beck; Thierry Fournier; Danielle Evain-Brion; Eva Dimitriadis; Jeffrey M Craig; Ruth Morley; Richard Saffery
Journal: J Biol Chem Date: 2009-02-23 Impact factor: 5.157