| Literature DB >> 9395378 |
L Weiss1, A Si-Mohamed, P Giral, P Castiel, A Ledur, C Blondin, M D Kazatchkine, N Haeffner-Cavaillon.
Abstract
Plasma levels of proinflammatory cytokines, cytokine inhibitors, and the beta chemokines RANTES, macrophage inhibitory protein (MIP)-1alpha, and monocyte chemoattractant protein (MCP)-1 were studied in relationship with virus load in 40 patients exhibiting plasma levels of HIV RNA ranging between undetectable and levels >10(6) copies/mL. Mean plasma levels of MCP-1 were increased in patients with high virus load compared with HIV-seropositive subjects with undetectable plasma viral RNA and healthy controls. MCP-1 levels were directly correlated with plasma levels of HIV RNA. No correlation was observed between virus load and plasma concentrations of MIP-1alpha and RANTES. The results suggest that low rates of viral replication in vivo are not dependent on increased production of the suppressive chemokines RANTES and MIP-1alpha. Since MCP-1 upregulates viral replication in vitro, the results may suggest a role for MCP-1 in triggering viral replication in HIV disease.Entities:
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Year: 1997 PMID： 9395378 DOI： 10.1086/517341
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226