| Literature DB >> 10535605 |
R C Gallo1, A Garzino-Demo, A L DeVico.
Abstract
Several chemotactic cytokines, or chemokines. inhibit HIV replication by blocking or down regulating chemokine receptors that serve as entry cofactors for the virus. Although the role of chemokine receptors in HIV pathogenesis has been the subject of intense interest, chemokines are comparatively less seriously considered as potential correlates of protection from HIV infection and disease progression. However, a critical analysis of newly available data reveals substantial evidence to support a beneficial role for chemokines in HIV infection and disease. In this review we summarize the results of such studies and their promising implications for HIV infection.Entities:
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Year: 1999 PMID: 10535605 DOI: 10.1023/a:1020539524373
Source DB: PubMed Journal: J Clin Immunol ISSN: 0271-9142 Impact factor: 8.317