BACKGROUND: The data base of the Eastern Cooperative Oncology Group (ECOG) provides access to data on a large adult patient population drawn from more than 25 major university institutions and hundreds of participating hospitals. Extensive medical files are maintained at the ECOG Coordinating Center and are updated regularly. METHODS: Data on 1414 eligible patients with acute myeloid leukemia (AML), treated on 6 ECOG protocols during the period 1976-1994, were reviewed to determine the number of long-term survivors (LTS) and to identify factors that predicted LTS. Disease free survival and factors impacting quality of life were examined as well. RESULTS: Of the 1414 patients, 274 survived for > or = 3 years and were considered LTS. A logistic regression analysis revealed that factors predicting LTS included age < 55 years, female gender, treatment between 1985 and 1990, white blood cell count < 10,000 cells/mm3, and hemoglobin > 10 g/dL. Disease free survival improved with escalating intensity of therapy. Quality-of-life data showed that infections were fairly common. Significant graft-versus-host disease occurred in 6 of 40 patients who received allogeneic bone marrow transplantation and contributed to the deaths of 4 individuals. Information on employment, insurance, social or marital difficulties, and psychosocial issues was more difficult to obtain. CONCLUSIONS: Prognosis in AML is a complex interaction involving the cellular origin of the malignant clone, morphology, and evolving therapeutic strategies. The most recent ECOG studies incorporate these variables and should provide additional insights into factors affecting LTS in patients with AML.
BACKGROUND: The data base of the Eastern Cooperative Oncology Group (ECOG) provides access to data on a large adult patient population drawn from more than 25 major university institutions and hundreds of participating hospitals. Extensive medical files are maintained at the ECOG Coordinating Center and are updated regularly. METHODS: Data on 1414 eligible patients with acute myeloid leukemia (AML), treated on 6 ECOG protocols during the period 1976-1994, were reviewed to determine the number of long-term survivors (LTS) and to identify factors that predicted LTS. Disease free survival and factors impacting quality of life were examined as well. RESULTS: Of the 1414 patients, 274 survived for > or = 3 years and were considered LTS. A logistic regression analysis revealed that factors predicting LTS included age < 55 years, female gender, treatment between 1985 and 1990, white blood cell count < 10,000 cells/mm3, and hemoglobin > 10 g/dL. Disease free survival improved with escalating intensity of therapy. Quality-of-life data showed that infections were fairly common. Significant graft-versus-host disease occurred in 6 of 40 patients who received allogeneic bone marrow transplantation and contributed to the deaths of 4 individuals. Information on employment, insurance, social or marital difficulties, and psychosocial issues was more difficult to obtain. CONCLUSIONS: Prognosis in AML is a complex interaction involving the cellular origin of the malignant clone, morphology, and evolving therapeutic strategies. The most recent ECOG studies incorporate these variables and should provide additional insights into factors affecting LTS in patients with AML.
Authors: Justin M Watts; Xin Victoria Wang; Mark R Litzow; Selina M Luger; Hillard M Lazarus; Peter A Cassileth; Hugo F Fernandez; Dan Douer; Lynette Zickl; Elisabeth Paietta; Jacob M Rowe; Martin S Tallman Journal: Leuk Res Date: 2014-06-02 Impact factor: 3.156
Authors: Timothy S Pardee; Rebecca G Anderson; Kristin M Pladna; Scott Isom; Lais P Ghiraldeli; Lance D Miller; Jeff W Chou; Guangxu Jin; Wei Zhang; Leslie R Ellis; Dmitriy Berenzon; Dianna S Howard; David D Hurd; Megan Manuel; Sarah Dralle; Susan Lyerly; Bayard L Powell Journal: Clin Cancer Res Date: 2018-02-06 Impact factor: 12.531
Authors: Amanda C Winters; Jonathan A Gutman; Enkhtsetseg Purev; Molly Nakic; Jennifer Tobin; Stephanie Chase; Jeff Kaiser; Lindsey Lyle; Chelsey Boggs; Keri Halsema; Jeffrey T Schowinsky; Julie Rosser; Mark D Ewalt; Bradford Siegele; Vishal Rana; Steven Schuster; Diana Abbott; Brett M Stevens; Craig T Jordan; Clayton Smith; Daniel A Pollyea Journal: Blood Adv Date: 2019-10-22
Authors: Hugo F Fernandez; Zhuoxin Sun; Xiaopan Yao; Mark R Litzow; Selina M Luger; Elisabeth M Paietta; Janis Racevskis; Gordon W Dewald; Rhett P Ketterling; John M Bennett; Jacob M Rowe; Hillard M Lazarus; Martin S Tallman Journal: N Engl J Med Date: 2009-09-24 Impact factor: 91.245
Authors: Dan Douer; Lynette N Zickl; Charles A Schiffer; Fredrick R Appelbaum; James H Feusner; Lois Shepherd; Cheryl L Willman; Clara D Bloomfield; Elisabeth Paietta; Robert E Gallagher; Jae H Park; Jacob M Rowe; Peter H Wiernik; Martin S Tallman Journal: Leuk Res Date: 2013-03-23 Impact factor: 3.156