| Literature DB >> 9389262 |
D Russell1, D Royston, P H Rees, S K Gupta, G N Kenny.
Abstract
Sixteen patients undergoing coronary revascularization requiring cardiopulmonary bypass received remifentanil 2 micrograms kg-1 or 5 micrograms kg-1 by infusion over 1 min after sternotomy but before commencing cardiopulmonary bypass, during hypothermic cardiopulmonary bypass and during cardiopulmonary bypass after rewarming. Hypothermic cardiopulmonary bypass reduced the clearance of remifentanil by an average of 20%, and this was attributed to the effect of temperature on blood and tissue esterase activity. Reductions in arterial pressure occurred with administration of both doses during normothermia only.Entities:
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Year: 1997 PMID： 9389262 DOI： 10.1093/bja/79.4.456
Source DB: PubMed Journal: Br J Anaesth ISSN： 0007-0912 Impact factor: 9.166