History of echocardiographic contrast agents.

Since its experimental introduction over 30 years ago, the use of cardiac ultrasound has expanded expeditiously, particularly in the last decade. The inception of managed care has fueled this expansion because ultrasound technology has the potential to enhance cost-effective diagnosis and medical care. Another important factor driving the growth of cardiac ultrasound has been the recent and rapid development of contrast echocardiography (CE). This diagnostic technique, involving the injection of a contrast agent to enhance ultrasound imaging, provides a safe, noninvasive means of directly assessing myocardial perfusion and a host of other aspects of cardiovascular health and integrity.