Literature DB >> 9383437

Combinatorial biosynthesis of 'unnatural' natural products: the polyketide example.

C J Tsoi1, C Khosla.   

Abstract

Multi-enzyme systems, such as those involved in the biosynthesis of polyketides, typically catalyze several distinct reactions that are combined in different ways to generate diverse natural products. The variability available in such systems has not been fully harnessed from nature. It may therefore be possible to create 'unnatural' natural products, which may be as structurally diverse and medicinally valuable as existing natural products, using combinatorial biosynthesis.

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Year:  1995        PMID： 9383437     DOI： 10.1016/1074-5521(95)90214-7

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  12 in total

1.  Naturally mosaic operons for secondary metabolite biosynthesis: variability and putative horizontal transfer of discrete catalytic domains of the epothilone polyketide synthase locus.

Authors:  J V Lopez
Journal:  Mol Genet Genomics       Date:  2003-11-01       Impact factor: 3.291

Review 2.  Engineering the acyltransferase substrate specificity of assembly line polyketide synthases.

Authors:  Briana J Dunn; Chaitan Khosla
Journal:  J R Soc Interface       Date:  2013-05-29       Impact factor: 4.118

3.  Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation.

Authors:  Leandro Vetcher; Zong-Qiang Tian; Robert McDaniel; Andreas Rascher; W Peter Revill; C Richard Hutchinson; Zhihao Hu
Journal:  Appl Environ Microbiol       Date:  2005-04       Impact factor: 4.792

4.  Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.

Authors:  Paul A Wender; Jeremy L Baryza; Stacey E Brenner; Brian A DeChristopher; Brian A Loy; Adam J Schrier; Vishal A Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-17       Impact factor: 11.205

Review 5.  Combinatorial biosynthesis of polyketides--a perspective.

Authors:  Fong T Wong; Chaitan Khosla
Journal:  Curr Opin Chem Biol       Date:  2012-02-16       Impact factor: 8.822

6.  Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes.

Authors:  Y Shen; P Yoon; T W Yu; H G Floss; D Hopwood; B S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

7.  Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.

Authors:  Bradley S Evans; Yunqiu Chen; William W Metcalf; Huimin Zhao; Neil L Kelleher
Journal:  Chem Biol       Date:  2011-05-27

8.  Antibiotic activity of polyketide products derived from combinatorial biosynthesis: implications for directed evolution.

Authors:  H Fu; C Khosla
Journal:  Mol Divers       Date:  1996-02       Impact factor: 2.943

9.  Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts.

Authors:  J T Kealey; L Liu; D V Santi; M C Betlach; P J Barr
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-20       Impact factor: 11.205

10.  Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016.

Authors:  S T Hong; J R Carney; S J Gould
Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490
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