Literature DB >> 9383421

New insight into the catalytic mechanism of chorismate mutases from structural studies.

A Y Lee1, J D Stewart, J Clardy, B Ganem.   

Abstract

Chorismate mutase catalyzes the rearrangement of chorismic acid to prephenic acid, which is the first committed step in the biosynthesis of aromatic amino acids. Its catalytic mechanism has been much studied, but is poorly understood. Recent structural information on enzymes from two species, and on an antibody that catalyzes the same reaction, has shed new light on this topic.

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Year:  1995        PMID： 9383421     DOI： 10.1016/1074-5521(95)90269-4

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  31 in total

1.  The mechanism of catalysis of the chorismate to prephenate reaction by the Escherichia coli mutase enzyme.

Authors:  Sun Hur; Thomas C Bruice
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

2.  Substrate conformational transitions in the active site of chorismate mutase: their role in the catalytic mechanism.

Authors:  H Guo; Q Cui; W N Lipscomb; M Karplus
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-31       Impact factor: 11.205

3.  Design, selection, and characterization of a split chorismate mutase.

Authors:  Manuel M Müller; Hajo Kries; Eva Csuhai; Peter Kast; Donald Hilvert
Journal:  Protein Sci       Date:  2010-05       Impact factor: 6.725

4.  Isotope effects on the enzymatic and nonenzymatic reactions of chorismate.

Authors:  S Kirk Wright; Michael S DeClue; Ajay Mandal; Lac Lee; Olaf Wiest; W Wallace Cleland; Donald Hilvert
Journal:  J Am Chem Soc       Date:  2005-09-21       Impact factor: 15.419

5.  Exploring the active site of chorismate mutase by combinatorial mutagenesis and selection: the importance of electrostatic catalysis.

Authors:  P Kast; M Asif-Ullah; N Jiang; D Hilvert
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

Review 6.  Enzymatic Cascade Reactions in Biosynthesis.

Authors:  Christopher T Walsh; Bradley S Moore
Journal:  Angew Chem Int Ed Engl       Date:  2019-02-20       Impact factor: 15.336

7.  Biochemical characterization of prephenate dehydrogenase from the hyperthermophilic bacterium Aquifex aeolicus.

Authors:  Julie Bonvin; Raphael A Aponte; Maria Marcantonio; Sasha Singh; Dinesh Christendat; Joanne L Turnbull
Journal:  Protein Sci       Date:  2006-06       Impact factor: 6.725

8.  Modification of residue 42 of the active site loop with a lysine-mimetic side chain rescues isochorismate-pyruvate lyase activity in Pseudomonas aeruginosa PchB.

Authors:  José Olucha; Kathleen M Meneely; Audrey L Lamb
Journal:  Biochemistry       Date:  2012-09-12       Impact factor: 3.162

9.  Location of the active site of allosteric chorismate mutase from Saccharomyces cerevisiae, and comments on the catalytic and regulatory mechanisms.

Authors:  Y Xue; W N Lipscomb
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

10.  Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy.

Authors:  Christopher K Prier; Todd K Hyster; Christopher C Farwell; Audrey Huang; Frances H Arnold
Journal:  Angew Chem Int Ed Engl       Date:  2016-03-11       Impact factor: 15.336
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