Literature DB >> 9383364

Towards a pharmacological genetics.

T J Mitchison1.   

Abstract

In the past, pharmacological approaches have been instrumental in identifying proteins involved in biological processes. Combinatorial chemistry has the potential to make this type of approach even more powerful.

Mesh：

Year:  1994        PMID： 9383364     DOI： 10.1016/1074-5521(94)90034-5

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  20 in total

1.  Establishment of a chemical synthetic lethality screen in cultured human cells.

Authors:  A Simons; N Dafni; I Dotan; Y Oron; D Canaani
Journal:  Genome Res       Date:  2001-02       Impact factor: 9.043

2.  "Mutagenesis" by peptide aptamers identifies genetic network members and pathway connections.

Authors:  C R Geyer; A Colman-Lerner; R Brent
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

3.  Small molecule developmental screens reveal the logic and timing of vertebrate development.

Authors:  R T Peterson; B A Link; J E Dowling; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-21       Impact factor: 11.205

4.  Powerful partners: Arabidopsis and chemical genomics.

Authors:  Stéphanie Robert; Natasha V Raikhel; Glenn R Hicks
Journal:  Arabidopsis Book       Date:  2009-01-21

5.  Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis.

Authors:  Xinhua Dai; Ken-ichiro Hayashi; Hiroshi Nozaki; Youfa Cheng; Yunde Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-14       Impact factor: 11.205

6.  Toward automated biochemotype annotation for large compound libraries.

Authors:  Xian Chen; Yizeng Liang; Jun Xu
Journal:  Mol Divers       Date:  2006-09-12       Impact factor: 2.943

7.  Inverse drug screens: a rapid and inexpensive method for implicating molecular targets.

Authors:  Dany S Adams; Michael Levin
Journal:  Genesis       Date:  2006-11       Impact factor: 2.487

8.  Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates.

Authors:  Dany S Adams; Kenneth R Robinson; Takahiro Fukumoto; Shipeng Yuan; R Craig Albertson; Pamela Yelick; Lindsay Kuo; Megan McSweeney; Michael Levin
Journal:  Development       Date:  2006-03-22       Impact factor: 6.868

9.  Chemical genetics: reshaping biology through chemistry.

Authors:  Stefan Florian; Stefan Hümmer; Mario Catarinella; Thomas U Mayer
Journal:  HFSP J       Date:  2007-07-12

10.  Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by Legionella pneumophila.

Authors:  Xavier Charpentier; Joëlle E Gabay; Moraima Reyes; Jing W Zhu; Arthur Weiss; Howard A Shuman
Journal:  PLoS Pathog       Date:  2009-07-03       Impact factor: 6.823
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