BACKGROUND: An association between serum parathyroid hormone (PTH) levels in normotensive elderly subjects and blood pressure values had been reported. OBJECTIVE: To examine the relationship between PTH levels and other biochemical markers of calcium metabolism in elderly subjects and 24 h ambulatory blood pressures. METHODS: We performed 24 h ambulatory blood pressure recordings for 123 independent elderly subjects aged 63-88 years using a SpaceLabs 90207 recorder. Mean night-time blood pressures were calculated from the average of readings during sleep; mean daytime blood pressures were calculated from the remaining recordings. Demographic data and details concerning the alcohol consumption and medication usage of the subjects were recorded. Serum PTH, 25-hydroxy-vitamin D, albumin, renin, aldosterone, noradrenaline, creatinine and calcium levels were measured. RESULTS: Fifty-five patients were being administered antihypertensive therapy. Serum PTH levels correlated to the nocturnal systolic blood pressure (SBP; beta = 0.29, P = 0.002), nocturnal diastolic blood pressure (DBP), daytime SBP and mean 24 h SBP on univariate and multivariate analysis. Aldosterone levels were related to nocturnal SBP in univariate analysis (beta = 0.21, P = 0.02) but the relationship was weakened when PTH levels were included in the analysis (beta = 0.16, P = 0.09). Nocturnal, daytime and mean 24 h blood pressures were not significantly related to serum calcium, 25-hydroxy-vitamin D, age, body mass index and alcohol consumption. Sex was a significant predictor of the DBP, men having higher levels than did women (daytime DBP beta = 0.29, P = 0.001). CONCLUSIONS: Serum PTH levels are related strongly to the blood pressure, particularly the nocturnal blood pressure in the elderly. It is not known whether PTH levels are a consequence or a cause of the elevation in blood pressure.
BACKGROUND: An association between serum parathyroid hormone (PTH) levels in normotensive elderly subjects and blood pressure values had been reported. OBJECTIVE: To examine the relationship between PTH levels and other biochemical markers of calcium metabolism in elderly subjects and 24 h ambulatory blood pressures. METHODS: We performed 24 h ambulatory blood pressure recordings for 123 independent elderly subjects aged 63-88 years using a SpaceLabs 90207 recorder. Mean night-time blood pressures were calculated from the average of readings during sleep; mean daytime blood pressures were calculated from the remaining recordings. Demographic data and details concerning the alcohol consumption and medication usage of the subjects were recorded. Serum PTH, 25-hydroxy-vitamin D, albumin, renin, aldosterone, noradrenaline, creatinine and calcium levels were measured. RESULTS: Fifty-five patients were being administered antihypertensive therapy. Serum PTH levels correlated to the nocturnal systolic blood pressure (SBP; beta = 0.29, P = 0.002), nocturnal diastolic blood pressure (DBP), daytime SBP and mean 24 h SBP on univariate and multivariate analysis. Aldosterone levels were related to nocturnal SBP in univariate analysis (beta = 0.21, P = 0.02) but the relationship was weakened when PTH levels were included in the analysis (beta = 0.16, P = 0.09). Nocturnal, daytime and mean 24 h blood pressures were not significantly related to serum calcium, 25-hydroxy-vitamin D, age, body mass index and alcohol consumption. Sex was a significant predictor of the DBP, men having higher levels than did women (daytime DBP beta = 0.29, P = 0.001). CONCLUSIONS: Serum PTH levels are related strongly to the blood pressure, particularly the nocturnal blood pressure in the elderly. It is not known whether PTH levels are a consequence or a cause of the elevation in blood pressure.
Authors: Olivier Moranne; Marc Froissart; Jerome Rossert; Cedric Gauci; Jean-Jacques Boffa; Jean Philippe Haymann; Mona Ben M'rad; Christian Jacquot; Pascal Houillier; Benedicte Stengel; Bruno Fouqueray Journal: J Am Soc Nephrol Date: 2008-11-12 Impact factor: 10.121
Authors: Adriana J van Ballegooijen; Bryan Kestenbaum; Michael C Sachs; Ian H de Boer; David S Siscovick; Andrew N Hoofnagle; Joachim H Ix; Marjolein Visser; Ingeborg A Brouwer Journal: J Am Coll Cardiol Date: 2014-01-27 Impact factor: 24.094
Authors: Anand Vaidya; Gary C Curhan; Julie M Paik; Henry Kronenberg; Eric N Taylor Journal: J Clin Endocrinol Metab Date: 2015-04-17 Impact factor: 5.958